Title |
Drug rash with eosinophilia and systemic symptoms (DRESS) in patients receiving strontium ranelate
|
---|---|
Published in |
Osteoporosis International, January 2013
|
DOI | 10.1007/s00198-013-2265-1 |
Pubmed ID | |
Authors |
P. Cacoub, V. Descamps, O. Meyer, C. Speirs, P. Belissa-Mathiot, P. Musette |
Abstract |
We have reviewed 47 drug rash with eosinophilia and systemic symptoms (DRESS) cases associated to strontium ranelate reported up to March 2011 to the Marketing Holder. The main signs were skin rash, fever, face oedema hypereosinophilia and liver involvement. For ten patients, persistence of DRESS symptoms was reported at the latest news obtained, and DRESS was identified as the direct cause of death in one case. The maximum incidence of DRESS associated with strontium ranelate was 1/24,112 [95 % CI (1/14,859; 1/42,194)] newly treated patients in France. Because DRESS is a severe drug reaction, the occurrence of a rash in a patient treated with strontium ranelate should lead to prompt and permanent treatment discontinuation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 33% |
France | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 19% |
Student > Master | 4 | 15% |
Student > Doctoral Student | 3 | 12% |
Other | 3 | 12% |
Professor | 2 | 8% |
Other | 3 | 12% |
Unknown | 6 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 42% |
Nursing and Health Professions | 3 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
Agricultural and Biological Sciences | 1 | 4% |
Unknown | 9 | 35% |