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X Demographics
Mendeley readers
Attention Score in Context
| Title |
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis
|
|---|---|
| Published in |
Nature Cell Biology, February 2013
|
| DOI | 10.1038/ncb2690 |
| Pubmed ID | |
| Authors |
Yun Zhang, Pengyuan Yang, Tao Sun, Dong Li, Xin Xu, Yaocheng Rui, Chaoran Li, Mengyang Chong, Toni Ibrahim, Laura Mercatali, Dino Amadori, Xincheng Lu, Dong Xie, Qi-Jing Li, Xiao-Fan Wang |
| Abstract |
The tumour stroma is an active participant during cancer progression. Stromal cells promote tumour progression and metastasis through multiple mechanisms including enhancing tumour invasiveness and angiogenesis, and suppressing immune surveillance. We report here that miR-126/miR-126(*), a microRNA pair derived from a single precursor, independently suppress the sequential recruitment of mesenchymal stem cells and inflammatory monocytes into the tumour stroma to inhibit lung metastasis by breast tumour cells in a mouse xenograft model. miR-126/miR-126(*) directly inhibit stromal cell-derived factor-1 alpha (SDF-1α) expression, and indirectly suppress the expression of chemokine (C-C motif) ligand 2 (Ccl2) by cancer cells in an SDF-1α-dependent manner. miR-126/miR-126(*) expression is downregulated in cancer cells by promoter methylation of their host gene Egfl7. These findings determine how this microRNA pair alters the composition of the primary tumour microenvironment to favour breast cancer metastasis, and demonstrate a correlation between miR-126/126(*) downregulation and poor metastasis-free survival of breast cancer patients. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 38% |
| United Kingdom | 1 | 13% |
| Japan | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 13% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 259 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| United Kingdom | 2 | <1% |
| Brazil | 1 | <1% |
| France | 1 | <1% |
| Germany | 1 | <1% |
| Belgium | 1 | <1% |
| Canada | 1 | <1% |
| Spain | 1 | <1% |
| China | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 248 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 74 | 29% |
| Researcher | 53 | 20% |
| Student > Master | 31 | 12% |
| Student > Bachelor | 19 | 7% |
| Student > Doctoral Student | 14 | 5% |
| Other | 43 | 17% |
| Unknown | 25 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 86 | 33% |
| Biochemistry, Genetics and Molecular Biology | 55 | 21% |
| Medicine and Dentistry | 46 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
| Engineering | 6 | 2% |
| Other | 24 | 9% |
| Unknown | 35 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 August 2019.
All research outputs
#3,669,679
of 22,696,971 outputs
Outputs from Nature Cell Biology
#1,577
of 3,812 outputs
Outputs of similar age
#40,437
of 286,375 outputs
Outputs of similar age from Nature Cell Biology
#12
of 42 outputs
Altmetric has tracked 22,696,971 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,812 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.0. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,375 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.