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The effect of Psoroptes ovis infestation on ovine epidermal barrier function

Overview of attention for article published in Veterinary Research, January 2013
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

Mentioned by

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4 tweeters
facebook
2 Facebook pages

Citations

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9 Dimensions

Readers on

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17 Mendeley
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Title
The effect of Psoroptes ovis infestation on ovine epidermal barrier function
Published in
Veterinary Research, January 2013
DOI 10.1186/1297-9716-44-11
Pubmed ID
Authors

Miriam R Stoeckli, Tom N McNeilly, David Frew, Edward J Marr, Alasdair J Nisbet, Adri HM van den Broek, Stewart TG Burgess

Abstract

Sheep scab is an intensively pruritic, exudative and allergic dermatitis of sheep caused by the ectoparasitic mite Psoroptes ovis. The purpose of the present study was to investigate the effect of P. ovis infestation on different components of the ovine epidermal barrier within the first 24 hours post-infestation (hpi). To achieve this, the expression of epidermal differentiation complex (EDC) genes and epidermal barrier proteins, the nature and severity of epidermal pathology and transepidermal water loss (TEWL) were evaluated.By 1 hpi a significant dermal polymorphonuclear infiltrate and a significant increase in TEWL with maximal mean TEWL (598.67 g/m2h) were observed. Epidermal pathology involving intra-epidermal pustulation, loss of epidermal architecture and damage to the basement membrane was seen by 3 hpi. Filaggrin and loricrin protein levels in the stratum corneum declined significantly in the first 24 hpi and qPCR validation confirmed the decrease in expression of the key EDC genes involucrin, filaggrin and loricrin observed by microarray analysis, with 5.8-fold, 4.5-fold and 80-fold decreases, respectively by 24 hpi.The present study has demonstrated that early P. ovis infestation disrupts the ovine epidermal barrier causing significant alterations in the expression of critical barrier components, epidermal pathology, and TEWL. Many of these features have also been documented in human and canine atopic dermatitis suggesting that sheep scab may provide a model for the elucidation of events occurring in the early phases of atopic sensitisation.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 6%
Belgium 1 6%
Unknown 15 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 41%
Researcher 4 24%
Other 1 6%
Professor 1 6%
Student > Master 1 6%
Other 2 12%
Unknown 1 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 47%
Veterinary Science and Veterinary Medicine 4 24%
Medicine and Dentistry 3 18%
Immunology and Microbiology 1 6%
Unknown 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 April 2020.
All research outputs
#4,880,226
of 15,542,315 outputs
Outputs from Veterinary Research
#271
of 942 outputs
Outputs of similar age
#76,968
of 253,716 outputs
Outputs of similar age from Veterinary Research
#9
of 27 outputs
Altmetric has tracked 15,542,315 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 942 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,716 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.