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Effect of patient age on treatment response in a study of the acute exacerbation of psychosis in schizophrenia

Overview of attention for article published in Schizophrenia Research, January 2017
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2 tweeters

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Title
Effect of patient age on treatment response in a study of the acute exacerbation of psychosis in schizophrenia
Published in
Schizophrenia Research, January 2017
DOI 10.1016/j.schres.2016.09.034
Pubmed ID
Authors

Steven D. Targum, Robert Risinger, Yangchun Du, J. Cara Pendergrass, Hassan H. Jamal, Bernard. L. Silverman

Abstract

Younger patients with schizophrenia have most likely experienced fewer adverse consequences of the illness than older patients who may have experienced a lifetime of treatment as well as socio-economic problems as a consequence of the illness. There is limited information regarding differential efficacy of long-acting injectable (LAI) antipsychotic medications across the age span in patients with schizophrenia. We conducted a post hoc age and gender analysis of treatment response to aripiprazole lauroxil (AL; ARISTADA®; Alkermes, Inc.), in a 12-week, double-blind, placebo-controlled, multinational, Phase 3 study evaluating two doses of AL (441mg and 882mg) versus placebo in adult patients experiencing an acute exacerbation of schizophrenia within the previous 2months. We examined change in the total Positive and Negative Syndrome Scale (PANSS) scores from baseline using analysis of covariance and categorical treatment response (defined as ≥30% total PANSS score improvement from baseline) in the following age groups: <30, 30-39, 40-49, and 50-69years old. Age and gender did not moderate the treatment response in this study. Both AL 441mg and AL 882mg showed an early and significant improvement of the mean total PANSS scores and categorical treatment responses compared to placebo in all four age groups, including younger patients regardless of gender that was sustained over the 85-day treatment period.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 58 100%

Demographic breakdown

Readers by professional status Count As %
Other 13 22%
Researcher 10 17%
Student > Bachelor 9 16%
Student > Ph. D. Student 8 14%
Student > Master 7 12%
Other 11 19%
Readers by discipline Count As %
Medicine and Dentistry 13 22%
Unspecified 12 21%
Pharmacology, Toxicology and Pharmaceutical Science 10 17%
Nursing and Health Professions 9 16%
Psychology 4 7%
Other 10 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2016.
All research outputs
#9,422,117
of 12,290,813 outputs
Outputs from Schizophrenia Research
#2,661
of 3,596 outputs
Outputs of similar age
#171,670
of 264,625 outputs
Outputs of similar age from Schizophrenia Research
#75
of 114 outputs
Altmetric has tracked 12,290,813 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,596 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,625 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 114 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.