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Anti-Diabetic Activity and Metabolic Changes Induced by Andrographis paniculata Plant Extract in Obese Diabetic Rats

Overview of attention for article published in Molecules, August 2016
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Title
Anti-Diabetic Activity and Metabolic Changes Induced by Andrographis paniculata Plant Extract in Obese Diabetic Rats
Published in
Molecules, August 2016
DOI 10.3390/molecules21081026
Pubmed ID
Authors

Muhammad Akhtar, Mohamad Bin Mohd Sarib, Intan Ismail, Faridah Abas, Amin Ismail, Nordin Lajis, Khozirah Shaari

Abstract

Andrographis paniculata is an annual herb and widely cultivated in Southeast Asian countries for its medicinal use. In recent investigations, A. paniculata was found to be effective against Type 1 diabetes mellitus (Type 1 DM). Here, we used a non-genetic out-bred Sprague-Dawley rat model to test the antidiabetic activity of A. paniculata against Type 2 diabetes mellitus (Type 2 DM). Proton Nuclear Magnetic Resonance (¹H-NMR) spectroscopy in combination with multivariate data analyses was used to evaluate the A. paniculata and metformin induced metabolic effects on the obese and obese-diabetic (obdb) rat models. Compared to the normal rats, high levels of creatinine, lactate, and allantoin were found in the urine of obese rats, whereas, obese-diabetic rats were marked by high glucose, choline and taurine levels, and low lactate, formate, creatinine, citrate, 2-oxoglutarate, succinate, dimethylamine, acetoacetate, acetate, allantoin and hippurate levels. Treatment of A. paniculata leaf water extract was found to be quite effective in restoring the disturbed metabolic profile of obdb rats back towards normal conditions. Thisstudy shows the anti-diabetic potential of A. paniculata plant extract and strengthens the idea of using this plant against the diabetes. Further classical genetic methods and state of the art molecular techniques could provide insights into the molecular mechanisms involved in the pathogenesis of diabetes mellitus and anti-diabetic effects of A. paniculata water extract.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 8 25%
Student > Master 6 19%
Student > Bachelor 5 16%
Student > Ph. D. Student 2 6%
Lecturer 2 6%
Other 9 28%
Readers by discipline Count As %
Unspecified 10 31%
Pharmacology, Toxicology and Pharmaceutical Science 8 25%
Chemistry 3 9%
Immunology and Microbiology 3 9%
Medicine and Dentistry 3 9%
Other 5 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2016.
All research outputs
#7,316,274
of 8,467,419 outputs
Outputs from Molecules
#2,819
of 4,012 outputs
Outputs of similar age
#207,614
of 253,774 outputs
Outputs of similar age from Molecules
#203
of 239 outputs
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