Title |
Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology
|
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Published in |
Journal of Neuroinflammation, February 2013
|
DOI | 10.1186/1742-2094-10-25 |
Pubmed ID | |
Authors |
Maria I Fonseca, Susan O McGuire, Scott E Counts, Andrea J Tenner |
Abstract |
Alzheimer's disease (AD) is a neurodegenerative dementia characterized by the decline of cognition and the presence of neuropathological changes including neuronal loss, neurofibrillary pathology and extracellular senile plaques. A neuroinflammatory process is also triggered and complement activation has been hypothesized to have a relevant role in this local inflammatory response. C5a, a proinflammatory anaphylatoxin generated after complement activation, exerts its chemotactic and inflammatory functions through the CD88 receptor while the more recently discovered C5L2 receptor has been postulated to have an anti-inflammatory role. Previously, we reported that a CD88 specific antagonist (PMX205) decreased the pathology and improved cognition in transgenic models of AD suggesting that C5a/C5aR interaction has an important role in the progression of the disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 1% |
United States | 1 | 1% |
Unknown | 67 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 23 | 33% |
Researcher | 10 | 14% |
Student > Master | 9 | 13% |
Student > Bachelor | 6 | 9% |
Other | 5 | 7% |
Other | 8 | 12% |
Unknown | 8 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 13 | 19% |
Agricultural and Biological Sciences | 13 | 19% |
Biochemistry, Genetics and Molecular Biology | 8 | 12% |
Medicine and Dentistry | 8 | 12% |
Immunology and Microbiology | 5 | 7% |
Other | 13 | 19% |
Unknown | 9 | 13% |