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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
|
|---|---|
| Published in |
PLOS ONE, April 2010
|
| DOI | 10.1371/journal.pone.0009979 |
| Pubmed ID | |
| Authors |
Patricia Spilman, Natalia Podlutskaya, Matthew J. Hart, Jayanta Debnath, Olivia Gorostiza, Dale Bredesen, Arlan Richardson, Randy Strong, Veronica Galvan |
| Abstract |
Reduced TOR signaling has been shown to significantly increase lifespan in a variety of organisms [1], [2], [3], [4]. It was recently demonstrated that long-term treatment with rapamycin, an inhibitor of the mTOR pathway[5], or ablation of the mTOR target p70S6K[6] extends lifespan in mice, possibly by delaying aging. Whether inhibition of the mTOR pathway would delay or prevent age-associated disease such as AD remained to be determined. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 11% |
| Venezuela, Bolivarian Republic of | 1 | 11% |
| Unknown | 7 | 78% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 89% |
| Scientists | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 596 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 1% |
| United States | 2 | <1% |
| Netherlands | 1 | <1% |
| Australia | 1 | <1% |
| Brazil | 1 | <1% |
| Ireland | 1 | <1% |
| India | 1 | <1% |
| Singapore | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Other | 5 | <1% |
| Unknown | 576 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 137 | 23% |
| Researcher | 103 | 17% |
| Student > Bachelor | 83 | 14% |
| Student > Master | 62 | 10% |
| Student > Doctoral Student | 25 | 4% |
| Other | 82 | 14% |
| Unknown | 104 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 163 | 27% |
| Biochemistry, Genetics and Molecular Biology | 103 | 17% |
| Neuroscience | 77 | 13% |
| Medicine and Dentistry | 53 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 23 | 4% |
| Other | 59 | 10% |
| Unknown | 118 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 260. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2024.
All research outputs
#143,450
of 25,784,004 outputs
Outputs from PLOS ONE
#2,208
of 224,770 outputs
Outputs of similar age
#311
of 104,483 outputs
Outputs of similar age from PLOS ONE
#8
of 704 outputs
Altmetric has tracked 25,784,004 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 224,770 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 104,483 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 704 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.