Title |
Antitumor effect and toxicity of free rhodium (II) citrate and rhodium (II) citrate-loaded maghemite nanoparticles in mice bearing breast cancer
|
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Published in |
Journal of Nanobiotechnology, February 2013
|
DOI | 10.1186/1477-3155-11-4 |
Pubmed ID | |
Authors |
Marcella Lemos Brettas Carneiro, Raphael CA Peixoto, Graziela A Joanitti, Ricardo GS Oliveira, Luis AM Telles, Ana L Miranda-Vilela, Anamélia L Bocca, Leonora MS Vianna, Izabel CR da Silva, Aparecido R de Souza, Zulmira GM Lacava, Sônia N Báo |
Abstract |
Magnetic fluids containing superparamagnetic iron oxide nanoparticles represent an attractive platform as nanocarriers in chemotherapy. Recently, we developed a formulation of maghemite nanoparticles coated with rhodium (II) citrate, which resulted in in vitro cytotoxicity enhanced up to 4.6 times when compared to free rhodium (II) citrate formulation on breast carcinoma cells. In this work, we evaluate the antitumor activity and toxicity induced by these formulations in Balb/c mice bearing orthotopic 4T1 breast carcinoma. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 51 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 12 | 24% |
Student > Bachelor | 5 | 10% |
Professor | 5 | 10% |
Student > Ph. D. Student | 5 | 10% |
Researcher | 4 | 8% |
Other | 6 | 12% |
Unknown | 14 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 14% |
Chemistry | 6 | 12% |
Biochemistry, Genetics and Molecular Biology | 5 | 10% |
Materials Science | 5 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 12 | 24% |
Unknown | 14 | 27% |