Title |
Periplakin is a target for autoimmunity in asthma
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Published in |
Respiratory Research, October 2016
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DOI | 10.1186/s12931-016-0441-5 |
Pubmed ID | |
Authors |
Camille Taillé, Sabine Grootenboer-Mignot, Candice Estellat, Carine Roy, Sophie Ly Ka So, Marina Pretolani, Michel Aubier, Bruno Crestani, Sylvie Chollet-Martin |
Abstract |
The role of autoimmunity targeting epithelial antigens in asthma has been suggested, in particular in non-atopic and severe asthma. Periplakin, a desmosomal component, is involved in epithelial cohesion and intracellular signaling. We detected anti-periplakin IgG antibodies in 47/260 (18 %) patients with asthma, with no association with severity or atopy. In addition, anti-periplakin IgE antibodies were detected in 12 of 138 tested patients (8.7 %) and were more frequently observed in patients with than without nasal polyposis. This study identifies a new autoimmune epithelial target in asthma. Whether periplakin autoimmunity (both IgG and IgE auto-antibodies) is involved in asthma pathogenesis remains to be studied during the disease course of these patients. |
X Demographics
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United Kingdom | 4 | 100% |
Demographic breakdown
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 4 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 1 | 25% |
Researcher | 1 | 25% |
Student > Postgraduate | 1 | 25% |
Unknown | 1 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 2 | 50% |
Immunology and Microbiology | 1 | 25% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 25% |