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Increased Drinking following Social Isolation Rearing: Implications for Polydipsia Associated with Schizophrenia

Overview of attention for article published in PLOS ONE, February 2013
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2 Facebook pages
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1 Redditor

Citations

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32 Mendeley
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Title
Increased Drinking following Social Isolation Rearing: Implications for Polydipsia Associated with Schizophrenia
Published in
PLOS ONE, February 2013
DOI 10.1371/journal.pone.0056105
Pubmed ID
Authors

Emily R. Hawken, Nicholas J. Delva, Richard J. Beninger

Abstract

Primary polydipsia, excessive drinking without known medical cause, is especially associated with a diagnosis of schizophrenia. We used animal models of schizophrenia-like symptoms to examine the effects on schedule-induced polydipsia: post-weaning social isolation rearing, subchronic MK-801 treatment (an NMDA-receptor antagonist) or the two combined. Male, Sprague-Dawley rats reared in groups or in isolation beginning at postnatal day 21 were further divided to receive subchronic MK-801 (0.5 mg/kg twice daily) or saline for 7 days beginning on postnatal day 62. Following a 4-day withdrawal period, all groups were trained on a schedule-induced polydipsia paradigm. Under food-restriction, animals reared in isolation and receiving food pellets at 1-min intervals developed significantly more drinking behavior than those reared with others. The addition of subchronic MK-801 treatment did not significantly augment the amount of water consumed. These findings suggest a predisposition to polydipsia is a schizophrenia-like behavioral effect of post-weaning social isolation.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
Unknown 31 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 19%
Student > Master 5 16%
Student > Doctoral Student 4 13%
Student > Bachelor 4 13%
Other 1 3%
Other 3 9%
Unknown 9 28%
Readers by discipline Count As %
Neuroscience 6 19%
Psychology 5 16%
Agricultural and Biological Sciences 5 16%
Medicine and Dentistry 3 9%
Unspecified 1 3%
Other 1 3%
Unknown 11 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2013.
All research outputs
#17,679,313
of 22,696,971 outputs
Outputs from PLOS ONE
#146,474
of 193,735 outputs
Outputs of similar age
#140,228
of 192,548 outputs
Outputs of similar age from PLOS ONE
#3,657
of 5,311 outputs
Altmetric has tracked 22,696,971 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,735 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,548 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,311 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.