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Promoter CpG Island Hypermethylation of the DNA Repair Enzyme MGMT Predicts Clinical Response to Dacarbazine in a Phase II Study for Metastatic Colorectal Cancer

Overview of attention for article published in Clinical Cancer Research, April 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

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12 X users
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9 Wikipedia pages

Citations

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98 Dimensions

Readers on

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83 Mendeley
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Title
Promoter CpG Island Hypermethylation of the DNA Repair Enzyme MGMT Predicts Clinical Response to Dacarbazine in a Phase II Study for Metastatic Colorectal Cancer
Published in
Clinical Cancer Research, April 2013
DOI 10.1158/1078-0432.ccr-12-3518
Pubmed ID
Authors

Alessio Amatu, Andrea Sartore-Bianchi, Catia Moutinho, Alessandro Belotti, Katia Bencardino, Giuseppe Chirico, Andrea Cassingena, Francesca Rusconi, Anna Esposito, Michele Nichelatti, Manel Esteller, Salvatore Siena

Abstract

O(6)-methylguanine-DNA-methyltransferase (MGMT) is a DNA repair protein removing mutagenic and cytotoxic adducts from O(6)-guanine in DNA. Approximately 40% of colorectal cancers (CRC) display MGMT deficiency due to the promoter hypermethylation leading to silencing of the gene. Alkylating agents, such as dacarbazine, exert their antitumor activity by DNA methylation at the O(6)-guanine site, inducing base pair mismatch; therefore, activity of dacarbazine could be enhanced in CRCs lacking MGMT. We conducted a phase II study with dacarbazine in CRCs who had failed standard therapies (oxaliplatin, irinotecan, fluoropyrimidines, and cetuximab or panitumumab if KRAS wild-type).

X Demographics

X Demographics

The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Unknown 81 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 20%
Student > Master 11 13%
Student > Ph. D. Student 10 12%
Student > Postgraduate 7 8%
Student > Bachelor 5 6%
Other 15 18%
Unknown 18 22%
Readers by discipline Count As %
Medicine and Dentistry 19 23%
Agricultural and Biological Sciences 19 23%
Biochemistry, Genetics and Molecular Biology 9 11%
Nursing and Health Professions 4 5%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 9 11%
Unknown 21 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2024.
All research outputs
#2,676,156
of 23,467,261 outputs
Outputs from Clinical Cancer Research
#2,353
of 12,741 outputs
Outputs of similar age
#22,747
of 198,903 outputs
Outputs of similar age from Clinical Cancer Research
#30
of 227 outputs
Altmetric has tracked 23,467,261 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,741 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.2. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,903 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 227 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.