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Nationwide distribution of varicella-zoster virus clades in China

Overview of attention for article published in BMC Infectious Diseases, October 2016
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Title
Nationwide distribution of varicella-zoster virus clades in China
Published in
BMC Infectious Diseases, October 2016
DOI 10.1186/s12879-016-1863-x
Pubmed ID
Authors

Songtao Xu, Mukai Chen, Huanying Zheng, Haiyan Wang, Meng Chen, Jianhui Zhou, Wang Shuang, Pengbo Yu, Chaofeng Ma, Jilan He, Daxing Feng, Zhu Zhen, Zhang Yan, Mao Naiying, Aili Cui, Qiuhua Wu, Mengyuan Qi, Chongshan Li, Xiaoguang Xu, Wenbo Xu

Abstract

In 2010, a universal nomenclature for varicella-zoster virus (VZV) clades was established, which is very useful in the monitoring of viral evolution, recombination, spread and genetic diversity. Currently, information about VZV clades has been disclosed worldwide, however, there are limited data regarding the characterization of circulating VZV clades in China, even where varicella remains widely epidemic. From 2008 to 2012, clinical samples with varicella or zoster were collected in General Hospital in eight provinces and analyzed by PCR, restriction endonuclease digestion and sequencing. The viral clades were determined by analysis of five single nucleotide polymorphisms (SNPs) within the 447-bp fragment of open reading frame (ORF) 22, and the restriction fragment length polymorphisms (RFLPs) of ORF 38 (PstI), ORF 54 (BglI) and ORF 62 (SmaI) were evaluated to understand genetic diversity of VZV and determinate varicella vaccine adverse event (VVAE). Seventy-seven varicella and 11 zoster samples were identified as being positive for VZV. The five SNPs profile showed that the majority of VZV strains belonged to clade 2, but clade 5 and clade 4 strains were also found in Guangdong. The RFLPs analysis of the DNA fragments of ORF 38, 54 and 62 showed that 85 of these samples were characterized as PstI + BglI + SamI-, and the remaining three VZV strains from varicella patients were characterized as PstI-BglI + SamI+ which is the genetic profile of VVAEs. The study suggested that the predominant clade 2 VZVs had been continually circulating since at least the 1950s in China. Nearly all VZV strains except VVAEs possessed the genetic profile of PstI + BglI + Sam-. However, the other clades were also found to be co-circulating with clade 2, especially in the border regions. These results highlighted the need for the constant and broad use of virologic surveillance to provide an important genetic baseline for varicella control and vaccination programs in China.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 30%
Researcher 2 20%
Student > Bachelor 1 10%
Student > Ph. D. Student 1 10%
Lecturer 1 10%
Other 1 10%
Unknown 1 10%
Readers by discipline Count As %
Medicine and Dentistry 2 20%
Nursing and Health Professions 2 20%
Agricultural and Biological Sciences 1 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 10%
Immunology and Microbiology 1 10%
Other 2 20%
Unknown 1 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2016.
All research outputs
#12,339,242
of 13,946,582 outputs
Outputs from BMC Infectious Diseases
#4,429
of 5,205 outputs
Outputs of similar age
#223,562
of 267,749 outputs
Outputs of similar age from BMC Infectious Diseases
#1
of 1 outputs
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