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Genetic Alterations during Colorectal-Tumor Development

Overview of attention for article published in New England Journal of Medicine, September 1988
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

news
1 news outlet
policy
2 policy sources
twitter
1 tweeter
patent
75 patents
wikipedia
1 Wikipedia page

Citations

dimensions_citation
5077 Dimensions

Readers on

mendeley
874 Mendeley
citeulike
2 CiteULike
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Title
Genetic Alterations during Colorectal-Tumor Development
Published in
New England Journal of Medicine, September 1988
DOI 10.1056/nejm198809013190901
Pubmed ID
Authors

Bert Vogelstein, Eric R. Fearon, Stanley R. Hamilton, Scott E. Kern, Ann C. Preisinger, Mark Leppert, Alida M.M. Smits, Johannes L. Bos

Abstract

Because most colorectal carcinomas appear to arise from adenomas, studies of different stages of colorectal neoplasia may shed light on the genetic alterations involved in tumor progression. We looked for four genetic alterations (ras-gene mutations and allelic deletions of chromosomes 5, 17, and 18) in 172 colorectal-tumor specimens representing various stages of neoplastic development. The specimens consisted of 40 predominantly early-stage adenomas from 7 patients with familial adenomatous polyposis, 40 adenomas (19 without associated foci of carcinoma and 21 with such foci) from 33 patients without familial polyposis, and 92 carcinomas resected from 89 patients. We found that ras-gene mutations occurred in 58 percent of adenomas larger than 1 cm and in 47 percent of carcinomas. However, ras mutations were found in only 9 percent of adenomas under 1 cm in size. Sequences on chromosome 5 that are linked to the gene for familial adenomatous polyposis were not lost in adenomas from the patients with polyposis but were lost in 29 to 35 percent of adenomas and carcinomas, respectively, from other patients. A specific region of chromosome 18 was deleted frequently in carcinomas (73 percent) and in advanced adenomas (47 percent) but only occasionally in earlier-stage adenomas (11 to 13 percent). Chromosome 17p sequences were usually lost only in carcinomas (75 percent). The four molecular alterations accumulated in a fashion that paralleled the clinical progression of tumors. These results are consistent with a model of colorectal tumorigenesis in which the steps required for the development of cancer often involve the mutational activation of an oncogene coupled with the loss of several genes that normally suppress tumorigenesis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 874 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 9 1%
Spain 6 <1%
United Kingdom 6 <1%
Germany 2 <1%
Austria 2 <1%
Italy 2 <1%
Hong Kong 1 <1%
Ireland 1 <1%
France 1 <1%
Other 11 1%
Unknown 833 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 188 22%
Student > Master 117 13%
Researcher 113 13%
Student > Bachelor 110 13%
Student > Doctoral Student 77 9%
Other 176 20%
Unknown 93 11%
Readers by discipline Count As %
Medicine and Dentistry 303 35%
Agricultural and Biological Sciences 195 22%
Biochemistry, Genetics and Molecular Biology 155 18%
Pharmacology, Toxicology and Pharmaceutical Science 16 2%
Immunology and Microbiology 15 2%
Other 73 8%
Unknown 117 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2020.
All research outputs
#715,449
of 15,405,681 outputs
Outputs from New England Journal of Medicine
#8,066
of 27,031 outputs
Outputs of similar age
#6,919
of 151,151 outputs
Outputs of similar age from New England Journal of Medicine
#168
of 302 outputs
Altmetric has tracked 15,405,681 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 27,031 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 78.9. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 151,151 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 302 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.