Title |
Modeling the evolution dynamics of exon-intron structure with a general random fragmentation process
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Published in |
BMC Ecology and Evolution, February 2013
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DOI | 10.1186/1471-2148-13-57 |
Pubmed ID | |
Authors |
Liya Wang, Lincoln D Stein |
Abstract |
Most eukaryotic genes are interrupted by spliceosomal introns. The evolution of exon-intron structure remains mysterious despite rapid advance in genome sequencing technique. In this work, a novel approach is taken based on the assumptions that the evolution of exon-intron structure is a stochastic process, and that the characteristics of this process can be understood by examining its historical outcome, the present-day size distribution of internal translated exons (exon). Through the combination of simulation and modeling the size distribution of exons in different species, we propose a general random fragmentation process (GRFP) to characterize the evolution dynamics of exon-intron structure. This model accurately predicts the probability that an exon will be split by a new intron and the distribution of novel insertions along the length of the exon. |
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