Title |
A functional genomics screen for microRNA regulators of NF-kappaB signaling
|
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Published in |
BMC Biology, February 2013
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DOI | 10.1186/1741-7007-11-19 |
Pubmed ID | |
Authors |
Anthony O Olarerin-George, Lauren Anton, Yih-Chii Hwang, Michal A Elovitz, John B Hogenesch |
Abstract |
The nuclear factor-KappaB (NF-κB) pathway is conserved from fruit flies to humans and is a key mediator of inflammatory signaling. Aberrant regulation of NF-κB is associated with several disorders including autoimmune disease, chronic inflammation, and cancer, making the NF-κB pathway an attractive therapeutic target. Many regulatory components of the NF-κB pathway have been identified, including microRNAs (miRNAs). miRNAs are small non-coding RNAs and are common components of signal transduction pathways. Here we present a cell-based functional genomics screen to systematically identify miRNAs that regulate NF-κB signaling. |
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Spain | 1 | 50% |
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Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
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Italy | 1 | 1% |
Mexico | 1 | 1% |
Denmark | 1 | 1% |
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Luxembourg | 1 | 1% |
Unknown | 64 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 25% |
Researcher | 13 | 19% |
Student > Master | 12 | 17% |
Professor > Associate Professor | 6 | 9% |
Professor | 4 | 6% |
Other | 6 | 9% |
Unknown | 11 | 16% |
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Immunology and Microbiology | 4 | 6% |
Computer Science | 2 | 3% |
Other | 4 | 6% |
Unknown | 12 | 17% |