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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Y2H-seq approach defines the human protein methyltransferase interactome
|
|---|---|
| Published in |
Nature Methods, March 2013
|
| DOI | 10.1038/nmeth.2397 |
| Pubmed ID | |
| Authors |
Mareike Weimann, Arndt Grossmann, Jonathan Woodsmith, Ziya Özkan, Petra Birth, David Meierhofer, Nouhad Benlasfer, Taras Valovka, Bernd Timmermann, Erich E Wanker, Sascha Sauer, Ulrich Stelzl |
| Abstract |
To accelerate high-density interactome mapping, we developed a yeast two-hybrid interaction screening approach involving short-read second-generation sequencing (Y2H-seq) with improved sensitivity and a quantitative scoring readout allowing rapid interaction validation. We applied Y2H-seq to investigate enzymes involved in protein methylation, a largely unexplored post-translational modification. The reported network of 523 interactions involving 22 methyltransferases or demethylases is comprehensively annotated and validated through coimmunoprecipitation experiments and defines previously undiscovered cellular roles of nonhistone protein methylation. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 50% |
| United States | 1 | 25% |
| Chile | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 183 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 1% |
| Portugal | 1 | <1% |
| Austria | 1 | <1% |
| Canada | 1 | <1% |
| Spain | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 176 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 29% |
| Researcher | 48 | 26% |
| Professor | 14 | 8% |
| Student > Master | 11 | 6% |
| Professor > Associate Professor | 10 | 5% |
| Other | 31 | 17% |
| Unknown | 16 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 92 | 50% |
| Biochemistry, Genetics and Molecular Biology | 49 | 27% |
| Medicine and Dentistry | 4 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
| Unspecified | 2 | 1% |
| Other | 11 | 6% |
| Unknown | 21 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2023.
All research outputs
#3,844,528
of 24,059,832 outputs
Outputs from Nature Methods
#2,912
of 5,132 outputs
Outputs of similar age
#30,936
of 197,697 outputs
Outputs of similar age from Nature Methods
#42
of 68 outputs
Altmetric has tracked 24,059,832 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,132 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.6. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,697 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.