Baseline Elevations of Leukotriene Metabolites and Altered Plasmalogens Are Prognostic Biomarkers of Plaque Progression in Systemic Lupus Erythematosus

https://t.co/aIEDVhSY20 "They had suggested that production of certain plasmalogens is elevated in response to the disease process, in order to combat inflammation."

https://t.co/aIEDVhSY20 "In a 2018 study of patients with metabolic syndrome, Candi et al. found the same two ethanolamine plasmalogens to be elevated in the diseased population when compared to healthy controls."

https://t.co/aIEDVhSY20 "Further study will be necessary to assess the utility of plasmalogens as biomarkers for both SLE and SLEPP." "Two plasmalogens, 1-(1-enyl-palmitoyl)-GPE and 1-(1-enyl-oleoyl)-GPE, were elevated in the SLEPP group."

https://t.co/aIEDVhSY20 "While our findings are consistent with the earlier reports, within our cohort these molecules are even further reduced in lupus patients who go on to develop atherosclerotic plaques."