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Enhanced Fluorescent Assignment of Protein Aggregates by an OligothiophenePorphyrin‐Based Amyloid Ligand

Overview of attention for article published in Macromolecular Rapid Communications, January 2013
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1 tweeter

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20 Mendeley
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Title
Enhanced Fluorescent Assignment of Protein Aggregates by an OligothiophenePorphyrin‐Based Amyloid Ligand
Published in
Macromolecular Rapid Communications, January 2013
DOI 10.1002/marc.201200817
Pubmed ID
Authors

Arja, Katriann, Sjölander, Daniel, Åslund, Alma, Prokop, Stefan, Heppner, Frank L., Konradsson, Peter, Lindgren, Mikael, Hammarström, Per, Åslund, K. O. Andreas, Nilsson, K. Peter R.

Abstract

Fluorescent probes identifying protein aggregates are of great interest, as deposition of aggregated proteins is associated with many devastating diseases. Here, we report that a fluorescent amyloid ligand composed of two distinct molecular moieties, an amyloidophilic pentameric oligothiophene and a porphyrin, can be utilized for spectral and lifetime imaging assessment of recombinant Aβ 1-42 amyloid fibrils and Aβ deposits in brain tissue sections from a transgenic mouse model with Alzheimer's disease pathology. The enhanced spectral range and distinct lifetime diversity of this novel oligothiophene-porphyrin-based ligand allow a more precise assessment of heterogeneous amyloid morphology compared with the corresponding oligothiophene dye.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sweden 1 5%
Argentina 1 5%
Unknown 18 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 40%
Researcher 5 25%
Student > Bachelor 2 10%
Student > Master 2 10%
Professor 1 5%
Other 2 10%
Readers by discipline Count As %
Chemistry 8 40%
Agricultural and Biological Sciences 7 35%
Medicine and Dentistry 2 10%
Engineering 2 10%
Biochemistry, Genetics and Molecular Biology 1 5%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2013.
All research outputs
#4,647,235
of 6,287,087 outputs
Outputs from Macromolecular Rapid Communications
#181
of 641 outputs
Outputs of similar age
#65,675
of 98,409 outputs
Outputs of similar age from Macromolecular Rapid Communications
#1
of 5 outputs
Altmetric has tracked 6,287,087 research outputs across all sources so far. This one is in the 14th percentile – i.e., 14% of other outputs scored the same or lower than it.
So far Altmetric has tracked 641 research outputs from this source. They receive a mean Attention Score of 1.9. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 98,409 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them