Title |
A review on the role of DANCR in the carcinogenesis
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Published in |
Cancer Cell International, May 2022
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DOI | 10.1186/s12935-022-02612-z |
Pubmed ID | |
Authors |
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Aria Baniahmad, Mohammad Taheri, Mohammad Samadian |
Abstract |
DANCR is an RNA gene located on chr4. This gene has several splice variants. Up-regulation of DANCR has been reported in many types of cancers. This lncRNA is mainly located in the cytoplasm and regulates genes expression at post-transcriptional level. In fact, it acts as a molecular sponge for a variety of miRNAs, including miR-874-3P, miR-335, miR-149, miR-4319, miR-758-3p, miR-216a-5p, miR-874-3p, miR-33a-5p, miR-335-5p, miR-145-3p, miR-665, miR-345-5p and miR-125b-5p. DANCR also regulates activity of PI3K/AKT/NF-κB, Wnt/β-catenin, ERK/SMAD, MAPK, IL-6/JAK1/STAT3, Smad2/3, p53, FAK/PI3K/AKT/GSK3β/Snail pathways. In the current narrative review article, we summarize the roles of DANCR in the carcinogenesis, with an especial emphasis on its role in the development of osteosarcoma and lung, liver, pancreatic and colorectal cancers. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 2 | 13% |
Student > Master | 2 | 13% |
Researcher | 1 | 6% |
Unknown | 11 | 69% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 4 | 25% |
Medicine and Dentistry | 1 | 6% |
Engineering | 1 | 6% |
Unknown | 10 | 63% |