↓ Skip to main content

Incident Cancer Risk and Signatures Among Older MUTYH Carriers: Analysis of Population-Based and Genomic Cohorts

Overview of attention for article published in Cancer Prevention Research, May 2022
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (60th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

Mentioned by

twitter
3 tweeters
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Incident Cancer Risk and Signatures Among Older MUTYH Carriers: Analysis of Population-Based and Genomic Cohorts
Published in
Cancer Prevention Research, May 2022
DOI 10.1158/1940-6207.capr-22-0080
Pubmed ID
Authors

Downie, Jonathan M., Riaz, Moeen, Xie, Jing, Lee, Minyi, Chan, Andrew T., Gibbs, Peter, Orchard, Suzanne G., Mahady, Suzanne E., Sebra, Robert P., Murray, Anne M., Macrae, Finlay, Schadt, Eric, Woods, Robyn L., McNeil, John J., Lacaze, Paul, Gala, Manish

Abstract

MUTYH carriers have an increased colorectal cancer (CRC) risk in case-control studies, with loss of heterozygosity (LOH) as the presumed mechanism. We evaluated cancer risk among carriers in a prospective, population-based cohort of older adults. Additionally, we assessed if cancers from carriers demonstrated mutational signatures (G:C>T:A transversions) associated with early LOH. We calculated incident risk of cancer and CRC among 13,131 sequenced study participants of the ASPirin in Reducing Events in the Elderly (ASPREE) cohort, stratified by sex and adjusting for age, smoking, alcohol use, BMI, polyp history, history of cancer, and aspirin use. MUTYH carriers were identified among 13,033 participants in The Cancer Genome Atlas and International Cancer Genome Consortium, and somatic signatures of cancers were analyzed. Male MUTYH carriers demonstrated an increased risk for overall cancer incidence (multivariable HR 1.66, 95% CI [1.03, 2.68]; P = 0.038) driven by increased CRC incidence (multivariable HR 3.55, 95% CI [1.42, 8.78]; P = 0.007), as opposed to extracolonic cancer incidence (multivariable HR 1.40, 95% CI [0.81, 2.44]; P = 0.229). Female carriers did not demonstrate increased risk of cancer, CRC, or extracolonic cancers. Analysis of mutation signatures from cancers of MUTYH carriers revealed no significant contribution toward early mutagenesis from widespread G:C>T:A transversions among gastrointestinal epithelial cancers. Among cancers from carriers, somatic transversions associated with base-excision repair deficiency are uncommon, suggestive of diverse mechanisms of carcinogenesis in carriers compared to those who inherit biallelic MUTYH mutations.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2022.
All research outputs
#12,146,823
of 21,419,046 outputs
Outputs from Cancer Prevention Research
#760
of 1,309 outputs
Outputs of similar age
#104,789
of 269,833 outputs
Outputs of similar age from Cancer Prevention Research
#8
of 17 outputs
Altmetric has tracked 21,419,046 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,309 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,833 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.