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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy
|
|---|---|
| Published in |
Skeletal Muscle, March 2013
|
| DOI | 10.1186/2044-5040-3-6 |
| Pubmed ID | |
| Authors |
C Florian Bentzinger, Shuo Lin, Klaas Romanino, Perrine Castets, Maitea Guridi, Serge Summermatter, Christoph Handschin, Lionel A Tintignac, Michael N Hall, Markus A Rüegg |
| Abstract |
Skeletal muscle mass is determined by the balance between protein synthesis and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of protein translation and has been implicated in the control of muscle mass. Inactivation of mTORC1 by skeletal muscle-specific deletion of its obligatory component raptor results in smaller muscles and a lethal dystrophy. Moreover, raptor-deficient muscles are less oxidative through changes in the expression PGC-1α, a critical determinant of mitochondrial biogenesis. These results suggest that activation of mTORC1 might be beneficial to skeletal muscle by providing resistance to muscle atrophy and increasing oxidative function. Here, we tested this hypothesis by deletion of the mTORC1 inhibitor tuberous sclerosis complex (TSC) in muscle fibers. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 21% |
| United States | 4 | 14% |
| Norway | 2 | 7% |
| Canada | 2 | 7% |
| Australia | 1 | 4% |
| Belgium | 1 | 4% |
| Finland | 1 | 4% |
| Switzerland | 1 | 4% |
| Argentina | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 7 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 61% |
| Scientists | 7 | 25% |
| Practitioners (doctors, other healthcare professionals) | 3 | 11% |
| Unknown | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 176 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 2% |
| Brazil | 3 | 2% |
| United States | 2 | 1% |
| Chile | 1 | <1% |
| Switzerland | 1 | <1% |
| Denmark | 1 | <1% |
| Portugal | 1 | <1% |
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 161 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 22% |
| Student > Master | 30 | 17% |
| Researcher | 26 | 15% |
| Student > Bachelor | 16 | 9% |
| Professor | 13 | 7% |
| Other | 34 | 19% |
| Unknown | 19 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 49 | 28% |
| Agricultural and Biological Sciences | 48 | 27% |
| Sports and Recreations | 18 | 10% |
| Medicine and Dentistry | 16 | 9% |
| Nursing and Health Professions | 4 | 2% |
| Other | 16 | 9% |
| Unknown | 25 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2015.
All research outputs
#1,724,350
of 22,699,621 outputs
Outputs from Skeletal Muscle
#35
of 360 outputs
Outputs of similar age
#14,640
of 194,888 outputs
Outputs of similar age from Skeletal Muscle
#1
of 4 outputs
Altmetric has tracked 22,699,621 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 360 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,888 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them