Title |
Amelioration of autoimmune neuroinflammation by the fusion molecule Fn14·TRAIL
|
---|---|
Published in |
Journal of Neuroinflammation, March 2013
|
DOI | 10.1186/1742-2094-10-36 |
Pubmed ID | |
Authors |
Hodaya Prinz-Hadad, Tehila Mizrachi, Michal Irony-Tur-Sinai, Tatyana B Prigozhina, Alexandra Aronin, Talma Brenner, Michal Dranitzki-Elhalel |
Abstract |
Multiple sclerosis (MS) is a, T cell-mediated autoimmune disease, the management of which remains challenging. The recently described fusion protein, Fn14·TRAIL, combining the extracellular domain of Fn14 (capable of blocking the pro-inflammatory TWEAK ligand) fused to the extracellular domain of the TRAIL ligand (capable of sending apoptotic signals through its receptors on activated inflammatory cells) was designed to modulate the immune system as an anti-inflammatory agent. The present study explores the efficacy of this purified protein as an anti-inflammatory agent, using the animal model of MS - experimental autoimmune encephalomyelitis (EAE). |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Netherlands | 1 | 4% |
Unknown | 25 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 15% |
Student > Master | 4 | 15% |
Student > Ph. D. Student | 3 | 12% |
Professor > Associate Professor | 3 | 12% |
Professor | 2 | 8% |
Other | 3 | 12% |
Unknown | 7 | 27% |
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Medicine and Dentistry | 4 | 15% |
Neuroscience | 3 | 12% |
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Immunology and Microbiology | 1 | 4% |
Other | 5 | 19% |
Unknown | 7 | 27% |