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Creatine Monohydrate and Conjugated Linoleic Acid Improve Strength and Body Composition Following Resistance Exercise in Older Adults

Overview of attention for article published in PLOS ONE, October 2007
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Title
Creatine Monohydrate and Conjugated Linoleic Acid Improve Strength and Body Composition Following Resistance Exercise in Older Adults
Published in
PLOS ONE, October 2007
DOI 10.1371/journal.pone.0000991
Pubmed ID
Authors

Mark Tarnopolsky, Andrew Zimmer, Jeremy Paikin, Adeel Safdar, Alissa Aboud, Erin Pearce, Brian Roy, Timothy Doherty

Abstract

Aging is associated with lower muscle mass and an increase in body fat. We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise training in older adults (>65 y). Men (N = 19) and women (N = 20) completed six months of resistance exercise training with CrM (5g/d)+CLA (6g/d) or placebo with randomized, double blind, allocation. Outcomes included: strength and muscular endurance, functional tasks, body composition (DEXA scan), blood tests (lipids, liver function, CK, glucose, systemic inflammation markers (IL-6, C-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-OH-2dG, 8-isoP) and bone resorption (Nu-telopeptides). Exercise training improved all measurements of functional capacity (P<0.05) and strength (P<0.001), with greater improvement for the CrM+CLA group in most measurements of muscular endurance, isokinetic knee extension strength, FFM, and lower fat mass (P<0.05). Plasma creatinine (P<0.05), but not creatinine clearance, increased for CrM+CLA, with no changes in serum CK activity or liver function tests. Together, this data confirms that supervised resistance exercise training is safe and effective for increasing strength in older adults and that a combination of CrM and CLA can enhance some of the beneficial effects of training over a six-month period. Trial Registration. ClinicalTrials.gov NCT00473902.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 217 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 <1%
United States 2 <1%
Ireland 1 <1%
United Kingdom 1 <1%
Portugal 1 <1%
Unknown 210 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 36 17%
Student > Bachelor 30 14%
Student > Ph. D. Student 28 13%
Researcher 22 10%
Student > Postgraduate 15 7%
Other 31 14%
Unknown 55 25%
Readers by discipline Count As %
Medicine and Dentistry 46 21%
Sports and Recreations 40 18%
Nursing and Health Professions 20 9%
Agricultural and Biological Sciences 20 9%
Social Sciences 7 3%
Other 20 9%
Unknown 64 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2016.
All research outputs
#12,580,762
of 22,701,287 outputs
Outputs from PLOS ONE
#97,233
of 193,818 outputs
Outputs of similar age
#58,946
of 71,750 outputs
Outputs of similar age from PLOS ONE
#182
of 228 outputs
Altmetric has tracked 22,701,287 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,818 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 71,750 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 228 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.