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Salmonella Infection Upregulates the Leaky Protein Claudin-2 in Intestinal Epithelial Cells

Overview of attention for article published in PLOS ONE, March 2013
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Title
Salmonella Infection Upregulates the Leaky Protein Claudin-2 in Intestinal Epithelial Cells
Published in
PLOS ONE, March 2013
DOI 10.1371/journal.pone.0058606
Pubmed ID
Authors

Yong-guo Zhang, Shaoping Wu, Yinglin Xia, Jun Sun

Abstract

Tight junctions seal the space between adjacent epithelial cells. Mounting evidence suggests that tight junction proteins play a key role in the pathogenesis of human disease. Claudin is a member of the tight junction protein family, which has 24 members in humans. To regulate cellular function, claudins interact structurally and functionally with membrane and scaffolding proteins via their cytoplasmic domain. In particular, claudin-2 is known to be a leaky protein that contributes to inflammatory bowel disease and colon cancer. However, the involvement of claudin-2 in bacterial infection in the intestine remains unknown.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 2%
Brazil 1 2%
Unknown 63 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 22%
Researcher 10 15%
Student > Bachelor 8 12%
Student > Doctoral Student 6 9%
Student > Master 6 9%
Other 9 14%
Unknown 12 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 28%
Biochemistry, Genetics and Molecular Biology 8 12%
Immunology and Microbiology 8 12%
Medicine and Dentistry 5 8%
Veterinary Science and Veterinary Medicine 4 6%
Other 7 11%
Unknown 15 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 June 2013.
All research outputs
#16,237,186
of 25,654,806 outputs
Outputs from PLOS ONE
#144,860
of 223,967 outputs
Outputs of similar age
#124,347
of 209,246 outputs
Outputs of similar age from PLOS ONE
#3,034
of 5,454 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 223,967 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,246 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,454 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.