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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Activation of Tumor-Cell STING Primes NK-Cell Therapy.
|
|---|---|
| Published in |
Cancer Immunology Research, June 2022
|
| DOI | 10.1158/2326-6066.cir-22-0017 |
| Pubmed ID | |
| Authors |
Erik H Knelson, Elena V Ivanova, Mubin Tarannum, Marco Campisi, Patrick H Lizotte, Matthew A Booker, Ismail Ozgenc, Moataz Noureddine, Brittany Meisenheimer, Minyue Chen, Brandon Piel, Nathaniel Spicer, Bonje Obua, Cameron M Messier, Erin Shannon, Navin R Mahadevan, Tetsuo Tani, Pieter J Schol, Anna M Lee-Hassett, Ari Zlota, Ha V Vo, Minh Ha, Arrien A Bertram, Saemi Han, Tran C Thai, Corinne E Gustafson, Kartika Venugopal, Timothy J Haggerty, Thomas P Albertson, Antja-Voy Hartley, Pinar O Eser, Ze-Hua Li, Israel Cañadas, Marina Vivero, Assunta De Rienzo, William G Richards, Adnan O Abu-Yousif, Vicky A Appleman, Richard C Gregory, Alexander Parent, Neil Lineberry, Eric L Smith, Pasi A Jänne, Juan J Miret, Michael Y Tolstorukov, Rizwan Romee, Cloud P Paweletz, Raphael Bueno, David A Barbie |
| Abstract |
Activation of the stimulator of interferon genes (STING) pathway promotes antitumor immunity but STING agonists have yet to achieve clinical success. Increased understanding of the mechanism of action of STING agonists in human tumors is key to developing therapeutic combinations that activate effective innate antitumor immunity. Here, we report that malignant pleural mesothelioma cells robustly express STING and are responsive to STING agonist treatment ex vivo. Using dynamic single-cell RNA sequencing of explants treated with a STING agonist we observed CXCR3 chemokine activation primarily in tumor cells and cancer-associated fibroblasts, as well as T-cell cytotoxicity. In contrast, primary NK cells resisted STING agonist-induced cytotoxicity. STING agonists enhanced migration and killing of NK cells and mesothelin-targeted chimeric antigen receptor (CAR)-NK cells, improving therapeutic activity in patient-derived organotypic tumor spheroids. These studies reveal the fundamental importance of using human tumor samples to assess innate and cellular immune therapies. By functionally profiling mesothelioma tumor explants with elevated STING expression in tumor cells, we uncovered distinct consequences of STING agonist treatment in humans that support testing combining STING agonists with NK and CAR-NK cell therapies. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 35% |
| India | 1 | 4% |
| Russia | 1 | 4% |
| United Kingdom | 1 | 4% |
| Hong Kong | 1 | 4% |
| Unknown | 13 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 62% |
| Scientists | 8 | 31% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 46 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 13% |
| Student > Bachelor | 6 | 13% |
| Researcher | 5 | 11% |
| Student > Doctoral Student | 3 | 7% |
| Student > Postgraduate | 2 | 4% |
| Other | 5 | 11% |
| Unknown | 19 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 22% |
| Medicine and Dentistry | 8 | 17% |
| Immunology and Microbiology | 6 | 13% |
| Agricultural and Biological Sciences | 1 | 2% |
| Unspecified | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 19 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2023.
All research outputs
#2,355,500
of 25,249,294 outputs
Outputs from Cancer Immunology Research
#248
of 1,518 outputs
Outputs of similar age
#50,499
of 436,914 outputs
Outputs of similar age from Cancer Immunology Research
#6
of 36 outputs
Altmetric has tracked 25,249,294 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,518 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 436,914 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.