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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice
|
|---|---|
| Published in |
Cancer Discovery, June 2022
|
| DOI | 10.1158/2159-8290.cd-21-1273 |
| Pubmed ID | |
| Authors |
Julia L. Drewes, Jie Chen, Nicholas O. Markham, Reece J. Knippel, Jada C. Domingue, Ada J. Tam, June L. Chan, Lana Kim, Madison McMann, Courtney Stevens, Christine M. Dejea, Sarah Tomkovich, John Michel, James R. White, Fuad Mohammad, Victoria L. Campodónico, Cody N. Heiser, Xinqun Wu, Shaoguang Wu, Hua Ding, Patricia Simner, Karen Carroll, Martha J. Shrubsole, Robert A. Anders, Seth T. Walk, Christian Jobin, Fengyi Wan, Robert J. Coffey, Franck Housseau, Ken S. Lau, Cynthia L. Sears |
| Abstract |
Defining the complex role of the microbiome in colorectal cancer (CRC) and the discovery of novel, pro-tumorigenic microbes are areas of active investigation. In the present study, culturing and reassociation experiments revealed that toxigenic strains of Clostridioides difficile drove the tumorigenic phenotype of a subset of CRC patient-derived mucosal slurries in germ-free ApcMin/+ mice. Tumorigenesis was dependent on the C. difficile toxin TcdB and was associated with induction of Wnt signaling, reactive oxygen species, and pro-tumorigenic mucosal immune responses marked by infiltration of activated myeloid cells and interleukin-17 (IL-17)-producing lymphoid and innate lymphoid cell subsets. These findings suggest that chronic colonization with toxigenic C. difficile is a potential driver of CRC in patients. |
X Demographics
The data shown below were collected from the profiles of 74 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 36 | 49% |
| United Kingdom | 3 | 4% |
| Cyprus | 1 | 1% |
| Dominican Republic | 1 | 1% |
| Mexico | 1 | 1% |
| India | 1 | 1% |
| Germany | 1 | 1% |
| Portugal | 1 | 1% |
| Saudi Arabia | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 26 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 35 | 47% |
| Scientists | 24 | 32% |
| Practitioners (doctors, other healthcare professionals) | 9 | 12% |
| Science communicators (journalists, bloggers, editors) | 6 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 53 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 17% |
| Researcher | 9 | 17% |
| Student > Doctoral Student | 5 | 9% |
| Professor > Associate Professor | 4 | 8% |
| Student > Master | 4 | 8% |
| Other | 10 | 19% |
| Unknown | 12 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 17% |
| Medicine and Dentistry | 8 | 15% |
| Immunology and Microbiology | 6 | 11% |
| Agricultural and Biological Sciences | 3 | 6% |
| Unspecified | 3 | 6% |
| Other | 6 | 11% |
| Unknown | 18 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 212. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2023.
All research outputs
#182,215
of 25,312,451 outputs
Outputs from Cancer Discovery
#63
of 4,041 outputs
Outputs of similar age
#5,430
of 438,856 outputs
Outputs of similar age from Cancer Discovery
#4
of 121 outputs
Altmetric has tracked 25,312,451 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,041 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.5. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 438,856 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.