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Mendeley readers
Attention Score in Context
| Title |
HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress
|
|---|---|
| Published in |
Free Radical Biology & Medicine, June 2011
|
| DOI | 10.1016/j.freeradbiomed.2011.06.015 |
| Pubmed ID | |
| Authors |
Tilman Grune, Betül Catalgol, Anke Licht, Gennady Ermak, Andrew M. Pickering, Jenny K. Ngo, Kelvin J.A. Davies |
| Abstract |
We report an entirely new role for the HSP70 chaperone in dissociating 26S proteasome complexes (into free 20S proteasomes and bound 19S regulators), preserving 19S regulators, and reconstituting 26S proteasomes in the first 1-3h after mild oxidative stress. These responses, coupled with direct 20S proteasome activation by poly(ADP ribose) polymerase in the nucleus and by PA28αβ in the cytoplasm, instantly provide cells with increased capacity to degrade oxidatively damaged proteins and to survive the initial effects of stress exposure. Subsequent adaptive (hormetic) processes (3-24h after stress exposure), mediated by several signal transduction pathways and involving increased transcription/translation of 20S proteasomes, immunoproteasomes, and PA28αβ, abrogate the need for 26S proteasome dissociation. During this adaptive period, HSP70 releases its bound 19S regulators, 26S proteasomes are reconstituted, and ATP-stimulated proteolysis is restored. The 26S proteasome-dependent, and ATP-stimulated, turnover of ubiquitinylated proteins is essential for normal cell metabolism, and its restoration is required for successful stress adaptation. |
Mendeley readers
The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Russia | 1 | <1% |
| Norway | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 119 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 24% |
| Researcher | 22 | 18% |
| Student > Master | 19 | 15% |
| Student > Bachelor | 12 | 10% |
| Professor | 6 | 5% |
| Other | 19 | 15% |
| Unknown | 16 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 30% |
| Biochemistry, Genetics and Molecular Biology | 33 | 27% |
| Medicine and Dentistry | 13 | 11% |
| Chemistry | 9 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 10 | 8% |
| Unknown | 18 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2016.
All research outputs
#16,721,208
of 25,371,288 outputs
Outputs from Free Radical Biology & Medicine
#3,743
of 5,447 outputs
Outputs of similar age
#91,916
of 127,016 outputs
Outputs of similar age from Free Radical Biology & Medicine
#30
of 36 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,447 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 127,016 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.