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HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress

Overview of attention for article published in Free Radical Biology & Medicine, October 2011
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Mentioned by

peer_reviews
1 peer review site
facebook
1 Facebook page

Citations

dimensions_citation
167 Dimensions

Readers on

mendeley
111 Mendeley
citeulike
1 CiteULike
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Title
HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress
Published in
Free Radical Biology & Medicine, October 2011
DOI 10.1016/j.freeradbiomed.2011.06.015
Pubmed ID
Authors

Tilman Grune, Betül Catalgol, Anke Licht, Gennady Ermak, Andrew M. Pickering, Jenny K. Ngo, Kelvin J.A. Davies

Abstract

We report an entirely new role for the HSP70 chaperone in dissociating 26S proteasome complexes (into free 20S proteasomes and bound 19S regulators), preserving 19S regulators, and reconstituting 26S proteasomes in the first 1-3h after mild oxidative stress. These responses, coupled with direct 20S proteasome activation by poly(ADP ribose) polymerase in the nucleus and by PA28αβ in the cytoplasm, instantly provide cells with increased capacity to degrade oxidatively damaged proteins and to survive the initial effects of stress exposure. Subsequent adaptive (hormetic) processes (3-24h after stress exposure), mediated by several signal transduction pathways and involving increased transcription/translation of 20S proteasomes, immunoproteasomes, and PA28αβ, abrogate the need for 26S proteasome dissociation. During this adaptive period, HSP70 releases its bound 19S regulators, 26S proteasomes are reconstituted, and ATP-stimulated proteolysis is restored. The 26S proteasome-dependent, and ATP-stimulated, turnover of ubiquitinylated proteins is essential for normal cell metabolism, and its restoration is required for successful stress adaptation.

Mendeley readers

The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 <1%
Russia 1 <1%
Norway 1 <1%
Switzerland 1 <1%
Unknown 107 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 25%
Student > Master 20 18%
Researcher 19 17%
Student > Bachelor 9 8%
Professor 6 5%
Other 17 15%
Unknown 12 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 36 32%
Biochemistry, Genetics and Molecular Biology 30 27%
Medicine and Dentistry 11 10%
Chemistry 9 8%
Business, Management and Accounting 2 2%
Other 9 8%
Unknown 14 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2016.
All research outputs
#7,356,432
of 12,252,710 outputs
Outputs from Free Radical Biology & Medicine
#2,242
of 3,294 outputs
Outputs of similar age
#70,733
of 138,610 outputs
Outputs of similar age from Free Radical Biology & Medicine
#13
of 23 outputs
Altmetric has tracked 12,252,710 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,294 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 138,610 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.