Role of Glucagon and Its Receptor in the Pathogenesis of Diabetes

the first incretin injectable med was to help folks with Type 1 diabetes: symlin (synthetic amylin). Loss of all pancreas beta cells in T1DM meant no amylin secretion. Amylin shuts off glucagon when insulin is secreted.

the incretins are supposed to help keep insulin flowing SLOWLY to match digested food release of glucose, protein amino acids & fat. our endogenous incretins have a short half-life & pharmacy companies spent years & $$ to make injectable medic

CRITICAL CONCEPT. the hormones of glucagon & insulin are driving much of the dysfunction of type 2 diabetes & part of type 1.... THE INCRETIN RESPONSES CAN SHUT DOWN PART OF TOO MUCH GLUCAGON & ARE TRIGGERED BY DIETARY FIBER! https://t.co/yRtf

RT @DanielJDrucker: While multiple NCEs that block GCGR signalling failed in clinical development due to mechanism-based toxicity, the auth…