I型IFN⬇️制御は長寿命の記憶細胞の生成が依存 →コロナ免疫記憶に影響 細胞免疫の堅牢さ コロナ感染運命を決定 https://t.co/IdX10iYvmI I型IFNはCD8 T細胞に直接作用 🦠感染に応じclone増殖と記憶形成を可能 https://t.co/pQPKDu1mu3 *複雑な免疫 番犬の様に制御困難 💉🔁breakthrough感染で混乱化
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@Anto_Berto @NaphiSoc “COVID-19 convalescent patients develop SARS-CoV-2-specific TSCM cells that display a non-exhausted phenotype.” But in fatal COVID-19 they are exhausted and die. I know it’s an hypothesis nobody wants to deal with, pre-circulation
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PC | The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection https://t.co/vvzFUKHkEz