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Memory elicitation, T-cell response and antibody production: an independent study of an inactivated entire virus vaccine (Coronavac)

Overview of attention for article published in Anais da Academia Brasileira de Ciências, January 2022
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Title
Memory elicitation, T-cell response and antibody production: an independent study of an inactivated entire virus vaccine (Coronavac)
Published in
Anais da Academia Brasileira de Ciências, January 2022
DOI 10.1590/0001-3765202220211590
Pubmed ID
Authors

Souza-Silva GA, Aquino RCA, Sousa GF, Barros BRS, Lima MRCF, Cruz LCO, Marcos BFS, Silva AJD, Tales AVS, Diniz MV, Lima MMC, Sá IWA, Rodrigues FAC, Souza EB, Nascimento AVD, Vieira AM, Carvalho BM, Campelo Júnior EB, Freitas AC, Melo CML

Abstract

Health professionals working to mitigate the COVID-19 pandemic are one of the main risk groups for the disease, being prioritized for vaccination. Considering this, the aim of this study was to analyze the immune response of these professionals immunized with CoronaVac in the first and second doses. Blood samples were collected after the first and second doses of the vaccine (CoronaVac) and used to investigate hematological and biochemical parameters, analysis of immunoglobulin production, cytokines, and gene expression profile, as well as the identification of subsets of immune cells. Post-first dose immunological phenotypic memory (CD27+) profiles (T CD4+, TCD8+ and CD19+) showed a significant increase, as did Monocyte APCs (CD80+HLA-DR+) in relation to the second dose. The cytokines IL-2, IL-6 and IFN-° showed increased values in relation to the other analyzed cytokines. The Th2/Th17 profile in the second dose was characterized by gene expression analysis. The production of IgM and IgG after vaccination showed statistically significant values in the comparison between doses. CoronaVac showed activation of APCs monocytes, memory response of T and B lymphocytes, with immunoglobulins production. This set of responses is characterized by the Th2/Th17 immunological profile.

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Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2022.
All research outputs
#14,118,594
of 21,738,040 outputs
Outputs from Anais da Academia Brasileira de Ciências
#8
of 30 outputs
Outputs of similar age
#154,531
of 299,236 outputs
Outputs of similar age from Anais da Academia Brasileira de Ciências
#1
of 1 outputs
Altmetric has tracked 21,738,040 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 30 research outputs from this source. They receive a mean Attention Score of 1.3. This one scored the same or higher as 22 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,236 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them