You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
| Title |
Memory elicitation, T-cell response and antibody production: an independent study of an inactivated entire virus vaccine (Coronavac).
|
|---|---|
| Published in |
Anais da Academia Brasileira de Ciências, June 2022
|
| DOI | 10.1590/0001-3765202220211590 |
| Pubmed ID | |
| Authors |
Guilherme Antonio DE Souza-Silva, Rodrigo Cesar A DE Aquino, Georon F DE Sousa, Bárbara Rafaela S Barros, Maríllia Raphaella C F DE Lima, Leonardo C O Cruz, Bianca F São Marcos, Anna Jéssica D Silva, Aparecida Virgínia S Tales, Madi V Diniz, Mônica Maria C Lima, Igor W A DE Sá, Fábio Augusto C Rodrigues, Edson B DE Souza, Arione V DO Nascimento, Amanda M Vieira, Bruno M DE Carvalho, Evônio B Campelo Júnior, Antonio Carlos DE Freitas, Cristiane M L DE Melo |
| Abstract |
Health professionals working to mitigate the COVID-19 pandemic are one of the main risk groups for the disease, being prioritized for vaccination. Considering this, the aim of this study was to analyze the immune response of these professionals immunized with CoronaVac in the first and second doses. Blood samples were collected after the first and second doses of the vaccine (CoronaVac) and used to investigate hematological and biochemical parameters, analysis of immunoglobulin production, cytokines, and gene expression profile, as well as the identification of subsets of immune cells. Post-first dose immunological phenotypic memory (CD27+) profiles (T CD4+, TCD8+ and CD19+) showed a significant increase, as did Monocyte APCs (CD80+HLA-DR+) in relation to the second dose. The cytokines IL-2, IL-6 and IFN-° showed increased values in relation to the other analyzed cytokines. The Th2/Th17 profile in the second dose was characterized by gene expression analysis. The production of IgM and IgG after vaccination showed statistically significant values in the comparison between doses. CoronaVac showed activation of APCs monocytes, memory response of T and B lymphocytes, with immunoglobulins production. This set of responses is characterized by the Th2/Th17 immunological profile. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 27% |
| Student > Bachelor | 2 | 18% |
| Student > Doctoral Student | 1 | 9% |
| Student > Ph. D. Student | 1 | 9% |
| Unknown | 4 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 27% |
| Biochemistry, Genetics and Molecular Biology | 1 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 9% |
| Psychology | 1 | 9% |
| Nursing and Health Professions | 1 | 9% |
| Other | 0 | 0% |
| Unknown | 4 | 36% |