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The effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammation

Overview of attention for article published in Nutrition & Metabolism, October 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

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3 news outlets
twitter
1 tweeter

Citations

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13 Dimensions

Readers on

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46 Mendeley
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Title
The effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammation
Published in
Nutrition & Metabolism, October 2016
DOI 10.1186/s12986-016-0137-3
Pubmed ID
Authors

Sandra Sánchez-Sarasúa, Salma Moustafa, Álvaro García-Avilés, María Fernanda López-Climent, Aurelio Gómez-Cadenas, Francisco E. Olucha-Bordonau, Ana M. Sánchez-Pérez

Abstract

Western diet and lifestyle are associated with overweight, obesity, and type 2 diabetes, which, in turn, are correlated with neuroinflammation processes. Exercise and a healthy diet are important in the prevention of these disorders. However, molecules inhibiting neuroinflammation might also be efficacious in the prevention and/or treatment of neurological disorders of inflammatory etiology. The abscisic acid (ABA) is a phytohormone involved in hydric-stress responses. This compound is not only found in plants but also in other organisms, including mammals. In rodents, ABA can play a beneficial role in the regulation of peripheral immune response and insulin action. Thus, we hypothesized that chronic ABA administration might exert a protective effect in a model of neuroinflammation induced by high-fat diet (HFD). Male Wistar rats were fed with standard diet or HFD with or without ABA in the drinking water for 12 weeks. Glucose tolerance test and behavioral paradigms were performed to evaluate the peripheral and central effects of treatments. One-Way ANOVA was performed analyzed statistical differences between groups. The HFD induced insulin resistance peripherally and increased the levels of proinflammatory markers in in the brain. We observed that ABA restored glucose tolerance in HFD-fed rats, as expected. In addition, chronic ABA treatment rescued cognitive performance in these animals, while not affecting control diet fed animals. Moreover, it counteracted the changes induced by HFD in the hypothalamus; microglia activations and TNFα mRNA levels. These results suggest that ABA might become a new therapeutic molecule improving the neuroinflammatory status and insulin resistance.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 20%
Student > Bachelor 6 13%
Researcher 5 11%
Student > Postgraduate 5 11%
Student > Ph. D. Student 5 11%
Other 10 22%
Unknown 6 13%
Readers by discipline Count As %
Neuroscience 16 35%
Biochemistry, Genetics and Molecular Biology 6 13%
Medicine and Dentistry 5 11%
Environmental Science 2 4%
Sports and Recreations 2 4%
Other 7 15%
Unknown 8 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2018.
All research outputs
#690,203
of 13,599,972 outputs
Outputs from Nutrition & Metabolism
#136
of 688 outputs
Outputs of similar age
#24,836
of 289,975 outputs
Outputs of similar age from Nutrition & Metabolism
#9
of 74 outputs
Altmetric has tracked 13,599,972 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 688 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.4. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,975 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.