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Regulation of behaviour by the nuclear receptor TLX

Overview of attention for article published in Genes, Brain & Behavior, November 2016
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  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
11 tweeters

Citations

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16 Dimensions

Readers on

mendeley
45 Mendeley
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Title
Regulation of behaviour by the nuclear receptor TLX
Published in
Genes, Brain & Behavior, November 2016
DOI 10.1111/gbb.12357
Pubmed ID
Authors

J. D. O'Leary, O. F. O'Leary, J. F. Cryan, Y. M. Nolan

Abstract

The orphan nuclear receptor Tlx (Nr2e1) is a key regulator of both embryonic and adult hippocampal neurogenesis. Several different mouse models have been developed which target Tlx in vivo including spontaneous deletion models (from birth) and targeted and conditional knockouts. Although some conflicting findings have been reported, for the most part studies have demonstrated that Tlx is important in regulating the processes that underlie neurogenesis, spatial learning, anxiety-like behaviour and interestingly, aggression. More recent data has demonstrated that disrupting Tlx during early life induces hyperactivity and has also shown that Tlx plays a role in emotional regulation. Moreover, there are sex and age-related differences in some behaviours in Tlx knockout mice during adolescence and adulthood. Here, we discuss the role of Tlx in motor, cognitive, aggressive and anxiety-related behaviours during adolescence and adulthood. We examine current evidence in the literature which provides insight into Tlx during neurodevelopment, and offer our thoughts on the function of Tlx in brain and behaviour. We further hypothesise that Tlx is a key target in understanding the emergence of neurobiological disorders during adolescence and early adulthood.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 20%
Student > Bachelor 8 18%
Student > Ph. D. Student 8 18%
Student > Doctoral Student 3 7%
Student > Master 3 7%
Other 5 11%
Unknown 9 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 13%
Psychology 6 13%
Neuroscience 6 13%
Biochemistry, Genetics and Molecular Biology 4 9%
Pharmacology, Toxicology and Pharmaceutical Science 4 9%
Other 5 11%
Unknown 14 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2018.
All research outputs
#5,133,803
of 20,567,241 outputs
Outputs from Genes, Brain & Behavior
#312
of 1,061 outputs
Outputs of similar age
#87,611
of 313,442 outputs
Outputs of similar age from Genes, Brain & Behavior
#6
of 10 outputs
Altmetric has tracked 20,567,241 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 1,061 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,442 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.