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Corticosteroids for Guillain-Barré syndrome

Overview of attention for article published in Cochrane database of systematic reviews, October 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

blogs
1 blog
twitter
13 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
151 Mendeley
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Title
Corticosteroids for Guillain-Barré syndrome
Published in
Cochrane database of systematic reviews, October 2016
DOI 10.1002/14651858.cd001446.pub5
Pubmed ID
Authors

Hughes, Richard Ac, Brassington, Ruth, Gunn, Angela A, van Doorn, Pieter A, Hughes, Richard AC

Abstract

Guillain-Barré syndrome (GBS) is an acute paralysing disease caused by inflammation of the peripheral nerves, which corticosteroids would be expected to benefit. To examine the ability of corticosteroids to hasten recovery and reduce the long-term morbidity from GBS. On 12 January 2016, we searched the Cochrane Neuromuscular Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and Embase. We also searched trials registries. We included randomised controlled trials (RCTs) or quasi-RCTs of any form of corticosteroid or adrenocorticotrophic hormone versus placebo or supportive care alone in GBS. Our primary outcome was change in disability grade on a seven-point scale after four weeks. Secondary outcomes included time from randomisation until recovery of unaided walking, time from randomisation until discontinuation of ventilation (for those ventilated), death, death or disability (inability to walk without aid) after 12 months, relapse, and adverse events. The review authors used standard methods expected by Cochrane. The review authors discovered no new trials in the new searches in June 2009, November 2011, or January 2016. Six trials with 587 participants provided data for the primary outcome. According to moderate quality evidence, the disability grade change after four weeks in the corticosteroid groups was not significantly different from that in the control groups, mean difference (MD) 0.36 less improvement (95% confidence intervals (CI) 0.16 more to 0.88 less improvement). In four trials of oral corticosteroids with 120 participants in total, there was very low quality evidence of less improvement after four weeks with corticosteroids than without corticosteroids, MD 0.82 disability grades less improvement (95% CI 0.17 to 1.47 grades less). In two trials with a combined total of 467 participants, there was moderate quality evidence of no significant difference of a disability grade more improvement after four weeks with intravenous corticosteroids (MD 0.17, 95% CI -0.06 to 0.39). According to moderate quality evidence, there was also no significant difference between the corticosteroid treated and control groups for improvement by one or more grades after four weeks (risk ratio (RR) 1.08, 95% CI 0.93 to 1.24) or for death or disability after one year (RR 1.51, 95% CI 0.91 to 2.5). We found high quality evidence that the occurrence of diabetes was more common (RR 2.21, 95% CI 1.19 to 4.12) and hypertension less common (RR 0.15, 95% CI 0.05 to 0.41) in the corticosteroid-treated participants. According to moderate quality evidence, corticosteroids given alone do not significantly hasten recovery from GBS or affect the long-term outcome. According to very low quality evidence, oral corticosteroids delay recovery. Diabetes requiring insulin was more common and hypertension less common with corticosteroids based on high quality evidence.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Germany 1 <1%
Italy 1 <1%
United Kingdom 1 <1%
United States 1 <1%
Unknown 146 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 27 18%
Student > Bachelor 25 17%
Researcher 19 13%
Student > Postgraduate 15 10%
Other 14 9%
Other 50 33%
Unknown 1 <1%
Readers by discipline Count As %
Medicine and Dentistry 81 54%
Unspecified 16 11%
Nursing and Health Professions 11 7%
Agricultural and Biological Sciences 9 6%
Pharmacology, Toxicology and Pharmaceutical Science 8 5%
Other 25 17%
Unknown 1 <1%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2018.
All research outputs
#902,812
of 12,362,966 outputs
Outputs from Cochrane database of systematic reviews
#2,444
of 8,523 outputs
Outputs of similar age
#33,738
of 273,214 outputs
Outputs of similar age from Cochrane database of systematic reviews
#53
of 143 outputs
Altmetric has tracked 12,362,966 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,523 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.2. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,214 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 143 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.