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Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis: The ACCESS Randomized Trial

Overview of attention for article published in JAMA: Journal of the American Medical Association, March 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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372 Mendeley
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Title
Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis: The ACCESS Randomized Trial
Published in
JAMA: Journal of the American Medical Association, March 2013
DOI 10.1001/jama.2013.2194
Pubmed ID
Authors

Steven M. Opal, Pierre-Francois Laterre, Bruno Francois, Steven P. LaRosa, Derek C. Angus, Jean-Paul Mira, Xavier Wittebole, Thierry Dugernier, Dominique Perrotin, Mark Tidswell, Luis Jauregui, Kenneth Krell, Jan Pachl, Takeshi Takahashi, Claus Peckelsen, Edward Cordasco, Chia-Sheng Chang, Sandra Oeyen, Naoki Aikawa, Tatsuya Maruyama, Roland Schein, Andre C. Kalil, Marc Van Nuffelen, Melvyn Lynn, Daniel P. Rossignol, Jagadish Gogate, Mary B. Roberts, Janice L. Wheeler, Jean-Louis Vincent, for the ACCESS Study Group

Abstract

Eritoran is a synthetic lipid A antagonist that blocks lipopolysaccharide (LPS) from binding at the cell surface MD2-TLR4 receptor. LPS is a major component of the outer membrane of gram-negative bacteria and is a potent activator of the acute inflammatory response.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 372 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 3 <1%
Canada 3 <1%
Australia 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
Denmark 1 <1%
Spain 1 <1%
Japan 1 <1%
Unknown 360 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 61 16%
Researcher 59 16%
Student > Bachelor 43 12%
Student > Master 39 10%
Other 29 8%
Other 69 19%
Unknown 72 19%
Readers by discipline Count As %
Medicine and Dentistry 138 37%
Biochemistry, Genetics and Molecular Biology 37 10%
Agricultural and Biological Sciences 33 9%
Immunology and Microbiology 30 8%
Pharmacology, Toxicology and Pharmaceutical Science 16 4%
Other 36 10%
Unknown 82 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 48. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2024.
All research outputs
#896,774
of 25,800,372 outputs
Outputs from JAMA: Journal of the American Medical Association
#7,883
of 36,827 outputs
Outputs of similar age
#6,207
of 211,386 outputs
Outputs of similar age from JAMA: Journal of the American Medical Association
#56
of 233 outputs
Altmetric has tracked 25,800,372 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 36,827 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 72.7. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 211,386 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 233 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.