Title |
Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis: The ACCESS Randomized Trial
|
---|---|
Published in |
JAMA: Journal of the American Medical Association, March 2013
|
DOI | 10.1001/jama.2013.2194 |
Pubmed ID | |
Authors |
Steven M. Opal, Pierre-Francois Laterre, Bruno Francois, Steven P. LaRosa, Derek C. Angus, Jean-Paul Mira, Xavier Wittebole, Thierry Dugernier, Dominique Perrotin, Mark Tidswell, Luis Jauregui, Kenneth Krell, Jan Pachl, Takeshi Takahashi, Claus Peckelsen, Edward Cordasco, Chia-Sheng Chang, Sandra Oeyen, Naoki Aikawa, Tatsuya Maruyama, Roland Schein, Andre C. Kalil, Marc Van Nuffelen, Melvyn Lynn, Daniel P. Rossignol, Jagadish Gogate, Mary B. Roberts, Janice L. Wheeler, Jean-Louis Vincent, for the ACCESS Study Group |
Abstract |
Eritoran is a synthetic lipid A antagonist that blocks lipopolysaccharide (LPS) from binding at the cell surface MD2-TLR4 receptor. LPS is a major component of the outer membrane of gram-negative bacteria and is a potent activator of the acute inflammatory response. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 14% |
United States | 1 | 14% |
Unknown | 5 | 71% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 57% |
Practitioners (doctors, other healthcare professionals) | 2 | 29% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 3 | <1% |
Canada | 3 | <1% |
Australia | 1 | <1% |
Brazil | 1 | <1% |
United Kingdom | 1 | <1% |
Denmark | 1 | <1% |
Spain | 1 | <1% |
Japan | 1 | <1% |
Unknown | 360 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 61 | 16% |
Researcher | 59 | 16% |
Student > Bachelor | 43 | 12% |
Student > Master | 39 | 10% |
Other | 29 | 8% |
Other | 69 | 19% |
Unknown | 72 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 138 | 37% |
Biochemistry, Genetics and Molecular Biology | 37 | 10% |
Agricultural and Biological Sciences | 33 | 9% |
Immunology and Microbiology | 30 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 16 | 4% |
Other | 36 | 10% |
Unknown | 82 | 22% |