Title |
Monitoring cartilage loss in the hands and wrists in rheumatoid arthritis with magnetic resonance imaging in a multi-center clinical trial: IMPRESS (NCT00425932)
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Published in |
Arthritis Research & Therapy, March 2013
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DOI | 10.1186/ar4202 |
Pubmed ID | |
Authors |
Charles G Peterfy, Ewa Olech, Julie C DiCarlo, Joan T Merrill, Peter J Countryman, Norman B Gaylis |
Abstract |
Magnetic resonance imaging (MRI) is increasingly being used in clinical trials of rheumatoid arthritis (RA) because of its superiority over x-ray radiography (XR) in detecting and monitoring change in bone erosion, osteitis and synovitis. However, in contrast to XR, the MRI scoring method that was used in most clinical trials did not include cartilage loss. This limitation has been an obstacle to accepting MRI as a potential alternative to XR in clinical trials. Cross-sectional studies have shown MRI to be sensitive for cartilage loss in the hands and wrist; although, longitudinal sensitivity to change has not yet been confirmed. In this study we examined the ability of MRI to monitor change in cartilage loss in patients with RA in a multi-site clinical trial setting. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 11 | 16% |
Researcher | 11 | 16% |
Student > Bachelor | 9 | 13% |
Other | 6 | 9% |
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Other | 11 | 16% |
Unknown | 17 | 25% |
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Psychology | 2 | 3% |
Other | 10 | 14% |
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