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Dynamin 2 Potentiates Invasive Migration of Pancreatic Tumor Cells through Stabilization of the Rac1 GEF Vav1

Overview of attention for article published in Developmental Cell, March 2013
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  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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4 tweeters

Citations

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41 Dimensions

Readers on

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48 Mendeley
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Title
Dynamin 2 Potentiates Invasive Migration of Pancreatic Tumor Cells through Stabilization of the Rac1 GEF Vav1
Published in
Developmental Cell, March 2013
DOI 10.1016/j.devcel.2013.02.010
Pubmed ID
Authors

Gina L. Razidlo, Yu Wang, Jing Chen, Eugene W. Krueger, Daniel D. Billadeau, Mark A. McNiven

Abstract

The large GTPase Dynamin 2 (Dyn2) is markedly upregulated in pancreatic cancer, is a potent activator of metastatic migration, and is required for Rac1-mediated formation of lamellipodia. Here we demonstrate an unexpected mechanism of Dyn2 action in these contexts via direct binding to the Rac1 guanine nucleotide exchange factor (GEF) Vav1. Surprisingly, disruption of the Dyn2-Vav1 interaction targets Vav1 to the lysosome for degradation via an interaction with the cytoplasmic chaperone Hsc70, resulting in a dramatic reduction of Vav1 protein stability. Importantly, a specific mutation in Vav1 near its Dyn2-binding C-terminal Src homology 3 (SH3) domain prevents Hsc70 binding, resulting in a stabilization of Vav1 levels. Dyn2 binding regulates the interaction of Vav1 with Hsc70 to control the stability and subsequent activity of this oncogenic GEF. These findings elucidate how Dyn2 activates Rac1, lamellipod protrusion, and invasive cellular migration and provide insight into how this specific Vav is ectopically expressed in pancreatic tumors.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 4 8%
United States 3 6%
India 1 2%
Argentina 1 2%
Unknown 39 81%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 40%
Student > Ph. D. Student 12 25%
Student > Doctoral Student 5 10%
Student > Bachelor 3 6%
Unspecified 3 6%
Other 6 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 52%
Biochemistry, Genetics and Molecular Biology 16 33%
Unspecified 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Social Sciences 1 2%
Other 1 2%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2013.
All research outputs
#6,480,821
of 12,088,915 outputs
Outputs from Developmental Cell
#1,710
of 2,823 outputs
Outputs of similar age
#55,989
of 130,911 outputs
Outputs of similar age from Developmental Cell
#30
of 48 outputs
Altmetric has tracked 12,088,915 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,823 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.1. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 130,911 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.