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Epidemiology and Evolution of Rotaviruses and Noroviruses from an Archival WHO Global Study in Children (1976–79) with Implications for Vaccine Design

Overview of attention for article published in PLOS ONE, March 2013
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  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

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Title
Epidemiology and Evolution of Rotaviruses and Noroviruses from an Archival WHO Global Study in Children (1976–79) with Implications for Vaccine Design
Published in
PLOS ONE, March 2013
DOI 10.1371/journal.pone.0059394
Pubmed ID
Authors

Lauren A. Rackoff, Karin Bok, Kim Y. Green, Albert Z. Kapikian

Abstract

Prompted by the discovery of new gastrointestinal viruses, the NIH, NIAID and WHO investigated the etiology of acute diarrhea that occurred from 1976-1979 in a global cohort of infants and young children. Rotaviruses were found to be major pathogens worldwide, whereas the Norwalk virus could not be detected using a radioimmunoassay. The aim of this study is to re-evaluate the role and diversity of rotaviruses and noroviruses in the original cohort using more sensitive current technologies. Stools collected from Asia, Africa, and South America (n = 485) were evaluated for viral genotypes by RT-PCR and sequencing. Rotaviruses were detected in 28.9% and noroviruses in 9.7% of the specimens, with G1 rotaviruses and GII noroviruses accounting for the majority of each respective virus. Various strains in this study predated the currently assigned dates of discovery for their particular genotype, and in addition, two noroviruses (KL45 and T091) could not be assigned to current genotypes. Phylogenetic analyses demonstrated a relative constancy in circulating rotavirus genotypes over time, with several genotypes from this study becoming established in the current repertoire of viral species. Similarly, GII noroviruses have maintained dominance, with GII.4 noroviruses continuing as a predominant genotype over time. Taken together, the complex molecular epidemiology of rotaviruses and noroviruses circulating in the 1970's is consistent with current patterns, an important consideration in the design of multivalent vaccines to control these viruses.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Brazil 2 2%
Vietnam 1 1%
Japan 1 1%
South Africa 1 1%
Unknown 89 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 23%
Student > Ph. D. Student 17 18%
Student > Master 16 17%
Student > Doctoral Student 7 7%
Student > Bachelor 6 6%
Other 15 16%
Unknown 13 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 27%
Medicine and Dentistry 22 23%
Biochemistry, Genetics and Molecular Biology 11 11%
Immunology and Microbiology 7 7%
Environmental Science 5 5%
Other 10 10%
Unknown 15 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2017.
All research outputs
#12,679,392
of 22,701,287 outputs
Outputs from PLOS ONE
#98,144
of 193,818 outputs
Outputs of similar age
#99,604
of 197,383 outputs
Outputs of similar age from PLOS ONE
#2,445
of 5,373 outputs
Altmetric has tracked 22,701,287 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,818 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,383 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,373 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.