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CRE/CREB-Driven Up-Regulation of Gene Expression by Chronic Social Stress in CRE-Luciferase Transgenic Mice: Reversal by Antidepressant Treatment

Overview of attention for article published in PLOS ONE, May 2007
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Title
CRE/CREB-Driven Up-Regulation of Gene Expression by Chronic Social Stress in CRE-Luciferase Transgenic Mice: Reversal by Antidepressant Treatment
Published in
PLOS ONE, May 2007
DOI 10.1371/journal.pone.0000431
Pubmed ID
Authors

Ulrike Böer, Tahseen Alejel, Stephan Beimesche, Irmgard Cierny, Doris Krause, Willhart Knepel, Gabriele Flügge

Abstract

It has been suggested that stress provokes neuropathological changes and may thus contribute to the precipitation of affective disorders such as depression. Likewise, the pharmacological therapy of depression requires chronic treatment and is thought to induce a positive neuronal adaptation, presumably based on changes in gene transcription. The transcription factor cAMP-responsive element binding protein (CREB) and its binding site (CRE) have been suggested to play a major role in both the development of depression and antidepressive therapy.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 2%
Unknown 48 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 24%
Researcher 11 22%
Student > Bachelor 5 10%
Student > Master 4 8%
Student > Doctoral Student 3 6%
Other 7 14%
Unknown 7 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 33%
Neuroscience 6 12%
Biochemistry, Genetics and Molecular Biology 6 12%
Medicine and Dentistry 5 10%
Psychology 3 6%
Other 6 12%
Unknown 7 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2013.
All research outputs
#15,266,089
of 22,701,287 outputs
Outputs from PLOS ONE
#130,093
of 193,818 outputs
Outputs of similar age
#62,129
of 71,907 outputs
Outputs of similar age from PLOS ONE
#114
of 129 outputs
Altmetric has tracked 22,701,287 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,818 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 71,907 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 129 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.