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Mendeley readers
| Title |
Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes
|
|---|---|
| Published in |
BMC Molecular and Cell Biology, May 2008
|
| DOI | 10.1186/1472-6807-8-26 |
| Pubmed ID | |
| Authors |
Zhen Xu, Ekta Kohli, Karl I Devlin, Michael Bold, Jay C Nix, Saurav Misra |
| Abstract |
Ubiquitin (E3) ligases interact with specific ubiquitin conjugating (E2) enzymes to ubiquitinate particular substrate proteins. As the combination of E2 and E3 dictates the type and biological consequence of ubiquitination, it is important to understand the basis of specificity in E2:E3 interactions. The E3 ligase CHIP interacts with Hsp70 and Hsp90 and ubiquitinates client proteins that are chaperoned by these heat shock proteins. CHIP interacts with two types of E2 enzymes, UbcH5 and Ubc13-Uev1a. It is unclear, however, why CHIP binds these E2 enzymes rather than others, and whether CHIP interacts preferentially with UbcH5 or Ubc13-Uev1a, which form different types of polyubiquitin chains. |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 1% |
| United States | 1 | 1% |
| India | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 75 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 24% |
| Researcher | 9 | 11% |
| Student > Bachelor | 8 | 10% |
| Student > Master | 8 | 10% |
| Student > Doctoral Student | 3 | 4% |
| Other | 11 | 14% |
| Unknown | 21 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 34% |
| Biochemistry, Genetics and Molecular Biology | 20 | 25% |
| Neuroscience | 2 | 3% |
| Engineering | 2 | 3% |
| Medicine and Dentistry | 2 | 3% |
| Other | 4 | 5% |
| Unknown | 22 | 28% |