Title |
The neuronal insulin sensitizer dicholine succinate reduces stress-induced depressive traits and memory deficit: possible role of insulin-like growth factor 2
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Published in |
BMC Neuroscience, September 2012
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DOI | 10.1186/1471-2202-13-110 |
Pubmed ID | |
Authors |
Brandon H Cline, Harry WM Steinbusch, Dmitry Malin, Alexander V Revishchin, Galia V Pavlova, Raymond Cespuglio, Tatyana Strekalova |
Abstract |
A number of epidemiological studies have established a link between insulin resistance and the prevalence of depression. The occurrence of depression was found to precede the onset of diabetes and was hypothesized to be associated with inherited inter-related insufficiency of the peripheral and central insulin receptors. Recently, dicholine succinate, a sensitizer of the neuronal insulin receptor, was shown to stimulate insulin-dependent H2O2 production of the mitochondrial respiratory chain leading to an enhancement of insulin receptor autophosphorylation in neurons. As such, this mechanism can be a novel target for the elevation of insulin signaling. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 1% |
Unknown | 74 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 11 | 15% |
Student > Ph. D. Student | 11 | 15% |
Student > Bachelor | 10 | 13% |
Researcher | 7 | 9% |
Other | 6 | 8% |
Other | 11 | 15% |
Unknown | 19 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 11 | 15% |
Neuroscience | 11 | 15% |
Agricultural and Biological Sciences | 10 | 13% |
Medicine and Dentistry | 10 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
Other | 6 | 8% |
Unknown | 22 | 29% |