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Dopamine Agonist Increases Risk Taking but Blunts Reward-Related Brain Activity

Overview of attention for article published in PLOS ONE, June 2008
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Citations

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Title
Dopamine Agonist Increases Risk Taking but Blunts Reward-Related Brain Activity
Published in
PLOS ONE, June 2008
DOI 10.1371/journal.pone.0002479
Pubmed ID
Authors

Jordi Riba, Ulrike M. Krämer, Marcus Heldmann, Sylvia Richter, Thomas F. Münte

Abstract

The use of D2/D3 dopaminergic agonists in Parkinson's disease (PD) may lead to pathological gambling. In a placebo-controlled double-blind study in healthy volunteers, we observed riskier choices in a lottery task after administration of the D3 receptor-preferring agonist pramipexole thus mimicking risk-taking behavior in PD. Moreover, we demonstrate decreased activation in the rostral basal ganglia and midbrain, key structures of the reward system, following unexpected high gains and therefore propose that pathological gambling in PD results from the need to seek higher rewards to overcome the blunted response in this system.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 162 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 3 2%
United States 3 2%
United Kingdom 3 2%
Italy 2 1%
Netherlands 1 <1%
Germany 1 <1%
Russia 1 <1%
Canada 1 <1%
Unknown 147 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 31 19%
Student > Ph. D. Student 28 17%
Student > Master 19 12%
Student > Doctoral Student 12 7%
Professor 11 7%
Other 40 25%
Unknown 21 13%
Readers by discipline Count As %
Psychology 41 25%
Agricultural and Biological Sciences 24 15%
Neuroscience 22 14%
Medicine and Dentistry 20 12%
Economics, Econometrics and Finance 4 2%
Other 21 13%
Unknown 30 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2013.
All research outputs
#20,187,333
of 22,703,044 outputs
Outputs from PLOS ONE
#172,974
of 193,827 outputs
Outputs of similar age
#79,044
of 82,182 outputs
Outputs of similar age from PLOS ONE
#449
of 460 outputs
Altmetric has tracked 22,703,044 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,827 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 82,182 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 460 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.