You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Hunger in the Absence of Caloric Restriction Improves Cognition and Attenuates Alzheimer's Disease Pathology in a Mouse Model
|
|---|---|
| Published in |
PLOS ONE, April 2013
|
| DOI | 10.1371/journal.pone.0060437 |
| Pubmed ID | |
| Authors |
Emily J. Dhurandhar, David B. Allison, Thomas van Groen, Inga Kadish |
| Abstract |
It has been shown that caloric restriction (CR) delays aging and possibly delays the development of Alzheimer's disease (AD). We conjecture that the mechanism may involve interoceptive cues, rather than reduced energy intake per se. We determined that hunger alone, induced by a ghrelin agonist, reduces AD pathology and improves cognition in the APP-SwDI mouse model of AD. Long-term treatment with a ghrelin agonist was sufficient to improve the performance in the water maze. The treatment also reduced levels of amyloid beta (Aβ) and inflammation (microglial activation) at 6 months of age compared to the control group, similar to the effect of CR. Thus, a hunger-inducing drug attenuates AD pathology, in the absence of CR, and the neuroendocrine aspects of hunger also prevent age-related cognitive decline. |
X Demographics
The data shown below were collected from the profiles of 32 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 16% |
| United States | 4 | 13% |
| Brazil | 2 | 6% |
| Netherlands | 2 | 6% |
| Australia | 1 | 3% |
| United Arab Emirates | 1 | 3% |
| Chile | 1 | 3% |
| Mexico | 1 | 3% |
| Finland | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 14 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 19 | 59% |
| Scientists | 9 | 28% |
| Science communicators (journalists, bloggers, editors) | 2 | 6% |
| Practitioners (doctors, other healthcare professionals) | 2 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Japan | 2 | 2% |
| Portugal | 1 | <1% |
| Canada | 1 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 123 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 17% |
| Researcher | 21 | 16% |
| Student > Bachelor | 18 | 14% |
| Student > Master | 13 | 10% |
| Other | 10 | 8% |
| Other | 24 | 18% |
| Unknown | 25 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 20% |
| Medicine and Dentistry | 22 | 17% |
| Psychology | 14 | 11% |
| Neuroscience | 11 | 8% |
| Nursing and Health Professions | 7 | 5% |
| Other | 21 | 16% |
| Unknown | 31 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 42. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2016.
All research outputs
#937,154
of 24,546,092 outputs
Outputs from PLOS ONE
#12,368
of 212,004 outputs
Outputs of similar age
#6,690
of 203,730 outputs
Outputs of similar age from PLOS ONE
#256
of 5,292 outputs
Altmetric has tracked 24,546,092 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 212,004 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 203,730 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 5,292 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.