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Topical capsaicin (high concentration) for chronic neuropathic pain in adults

Overview of attention for article published in this source, February 2013
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Mentioned by

1 blog
27 tweeters
3 Facebook pages
1 Wikipedia page


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Readers on

208 Mendeley
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Topical capsaicin (high concentration) for chronic neuropathic pain in adults
Published by
John Wiley & Sons, Ltd, February 2013
DOI 10.1002/14651858.cd007393.pub3
Pubmed ID

Derry, Sheena, Rice, Andrew S C, Cole, Peter, Tan, Toni, Moore, R Andrew


Topical creams with capsaicin are used to treat peripheral neuropathic pain. Following application to the skin capsaicin causes enhanced sensitivity, followed by a period with reduced sensitivity and, after repeated applications, persistent desensitisation. High-concentration (8%) capsaicin patches were developed to increase the amount of capsaicin delivered; rapid delivery was thought to improve tolerability because cutaneous nociceptors are 'defunctionalised' quickly. The single application avoids noncompliance. Only the 8% patch formulation of capsaicin is available, with a capsaicin concentration about 100 times greater than conventional creams.High-concentration topical capsaicin is given as a single patch application to the affected part. It must be applied under highly controlled conditions, normally under local anaesthetic, due to the initial intense burning sensation it causes. The benefits are expected to last for about 12 weeks, when another application might be made.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 208 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 1%
Germany 2 <1%
South Africa 1 <1%
Brazil 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 199 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 32 15%
Student > Master 31 15%
Student > Bachelor 27 13%
Student > Ph. D. Student 26 13%
Other 19 9%
Other 48 23%
Unknown 25 12%
Readers by discipline Count As %
Medicine and Dentistry 93 45%
Nursing and Health Professions 16 8%
Agricultural and Biological Sciences 13 6%
Psychology 13 6%
Pharmacology, Toxicology and Pharmaceutical Science 11 5%
Other 31 15%
Unknown 31 15%