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Topical capsaicin (high concentration) for chronic neuropathic pain in adults

Overview of attention for article published in this source, February 2013
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26 X users
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1 Wikipedia page


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Topical capsaicin (high concentration) for chronic neuropathic pain in adults
Published by
John Wiley & Sons, Ltd, February 2013
DOI 10.1002/14651858.cd007393.pub3
Pubmed ID

Derry, Sheena, Rice, Andrew S C, Cole, Peter, Tan, Toni, Moore, R Andrew


Topical creams with capsaicin are used to treat peripheral neuropathic pain. Following application to the skin capsaicin causes enhanced sensitivity, followed by a period with reduced sensitivity and, after repeated applications, persistent desensitisation. High-concentration (8%) capsaicin patches were developed to increase the amount of capsaicin delivered; rapid delivery was thought to improve tolerability because cutaneous nociceptors are 'defunctionalised' quickly. The single application avoids noncompliance. Only the 8% patch formulation of capsaicin is available, with a capsaicin concentration about 100 times greater than conventional creams.High-concentration topical capsaicin is given as a single patch application to the affected part. It must be applied under highly controlled conditions, normally under local anaesthetic, due to the initial intense burning sensation it causes. The benefits are expected to last for about 12 weeks, when another application might be made.

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Geographical breakdown

Country Count As %
United Kingdom 3 1%
Germany 2 <1%
South Africa 1 <1%
Brazil 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 214 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 33 15%
Student > Master 31 14%
Student > Bachelor 28 13%
Student > Ph. D. Student 27 12%
Other 21 9%
Other 51 23%
Unknown 32 14%
Readers by discipline Count As %
Medicine and Dentistry 97 43%
Nursing and Health Professions 17 8%
Psychology 14 6%
Agricultural and Biological Sciences 13 6%
Neuroscience 11 5%
Other 32 14%
Unknown 39 17%