Title |
Slow CCL2-dependent translocation of biopersistent particles from muscle to brain
|
---|---|
Published in |
BMC Medicine, April 2013
|
DOI | 10.1186/1741-7015-11-99 |
Pubmed ID | |
Authors |
Zakir Khan, Christophe Combadière, François-Jérôme Authier, Valérie Itier, François Lux, Christopher Exley, Meriem Mahrouf-Yorgov, Xavier Decrouy, Philippe Moretto, Olivier Tillement, Romain K Gherardi, Josette Cadusseau |
Abstract |
Long-term biodistribution of nanomaterials used in medicine is largely unknown. This is the case for alum, the most widely used vaccine adjuvant, which is a nanocrystalline compound spontaneously forming micron/submicron-sized agglomerates. Although generally well tolerated, alum is occasionally detected within monocyte-lineage cells long after immunization in presumably susceptible individuals with systemic/neurologic manifestations or autoimmune (inflammatory) syndrome induced by adjuvants (ASIA). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 100 | 21% |
United Kingdom | 14 | 3% |
Canada | 12 | 3% |
France | 6 | 1% |
Japan | 5 | 1% |
Italy | 3 | <1% |
Australia | 3 | <1% |
India | 2 | <1% |
Spain | 2 | <1% |
Other | 21 | 4% |
Unknown | 307 | 65% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 427 | 90% |
Practitioners (doctors, other healthcare professionals) | 30 | 6% |
Scientists | 10 | 2% |
Science communicators (journalists, bloggers, editors) | 7 | 1% |
Unknown | 1 | <1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
France | 1 | 1% |
Belgium | 1 | 1% |
Australia | 1 | 1% |
Unknown | 90 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 20 | 21% |
Student > Ph. D. Student | 17 | 18% |
Other | 10 | 11% |
Student > Master | 9 | 10% |
Student > Doctoral Student | 8 | 9% |
Other | 14 | 15% |
Unknown | 16 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 29% |
Agricultural and Biological Sciences | 17 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 7% |
Immunology and Microbiology | 7 | 7% |
Nursing and Health Professions | 3 | 3% |
Other | 15 | 16% |
Unknown | 18 | 19% |