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Comparison of paper spray mass spectrometry analysis of dried blood spots from devices used for in-field collection of clinical samples

Overview of attention for article published in Analytical & Bioanalytical Chemistry, November 2016
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  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

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Title
Comparison of paper spray mass spectrometry analysis of dried blood spots from devices used for in-field collection of clinical samples
Published in
Analytical & Bioanalytical Chemistry, November 2016
DOI 10.1007/s00216-016-9954-5
Pubmed ID
Authors

Karen E. Yannell, Kristina R. Kesely, Huynh Dinh Chien, Candice B. Kissinger, R. Graham Cooks

Abstract

Paper spray (PS) is an ambient ionization technique applicable to ionizing analytes from untreated dried biofluid samples. In-field sample analysis could benefit from the capability to use a finger prick of blood to measure drugs in whole blood at low cost and in a short time. Some studies may require specialized blood collection devices that can be used in remote areas. In this study, four different dried blood spot (DBS) devices are used with PS sources and tested for rapid quantification of imatinib and N-desmethyl-imatinib. A triple quadrupole mass spectrometer allows analyte detection with high sensitivity. Analytical figures of merit for the four devices are compared, and it is concluded that several of the novel devices successfully deploy DBS with PS and yield similar results to traditional manual PS methods. Clinical samples collected in a remote location were analyzed as a proof of concept for in-field blood collection and subsequent rapid laboratory analysis. Graphical abstract Dried blood spot analyis by paper spray ionization MS/MS for in field sample collection.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Uruguay 1 2%
Canada 1 2%
Unknown 47 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 20%
Student > Master 9 18%
Researcher 6 12%
Student > Bachelor 5 10%
Lecturer 3 6%
Other 5 10%
Unknown 11 22%
Readers by discipline Count As %
Chemistry 20 41%
Agricultural and Biological Sciences 4 8%
Medicine and Dentistry 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Nursing and Health Professions 2 4%
Other 4 8%
Unknown 12 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2017.
All research outputs
#19,944,994
of 25,374,647 outputs
Outputs from Analytical & Bioanalytical Chemistry
#6,060
of 9,619 outputs
Outputs of similar age
#232,502
of 318,602 outputs
Outputs of similar age from Analytical & Bioanalytical Chemistry
#72
of 194 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,619 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,602 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 194 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.