Title |
Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages
|
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Published in |
Particle and Fibre Toxicology, December 2005
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DOI | 10.1186/1743-8977-2-11 |
Pubmed ID | |
Authors |
Peter G Barlow, Anna Clouter-Baker, Ken Donaldson, Janis MacCallum, Vicki Stone |
Abstract |
Alveolar macrophages are a key cell in dealing with particles deposited in the lungs and in determining the subsequent response to that particle exposure. Nanoparticles are considered a potential threat to the lungs and the mechanism of pulmonary response to nanoparticles is currently under intense scrutiny. The type II alveolar epithelial cell has previously been shown to release chemoattractants which can recruit alveolar macrophages to sites of particle deposition. The aim of this study was to assess the responses of a type II epithelial cell line (L-2) to both fine and nanoparticle exposure in terms of secretion of chemotactic substances capable of inducing macrophage migration. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 1% |
Indonesia | 1 | 1% |
Australia | 1 | 1% |
United Kingdom | 1 | 1% |
Japan | 1 | 1% |
Unknown | 71 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 26% |
Researcher | 12 | 16% |
Student > Bachelor | 9 | 12% |
Student > Doctoral Student | 6 | 8% |
Student > Master | 6 | 8% |
Other | 16 | 21% |
Unknown | 7 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 16% |
Biochemistry, Genetics and Molecular Biology | 10 | 13% |
Medicine and Dentistry | 9 | 12% |
Engineering | 6 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
Other | 20 | 26% |
Unknown | 14 | 18% |