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Protein carbonyl content: a novel biomarker for aging in HIV/AIDS patients

Overview of attention for article published in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, November 2016
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Title
Protein carbonyl content: a novel biomarker for aging in HIV/AIDS patients
Published in
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, November 2016
DOI 10.1016/j.bjid.2016.09.007
Pubmed ID
Authors

Kolgiri, Vaishali, Patil, V W, Vaishali Kolgiri, Vinayak Wamanrao Patil

Abstract

The major complications of "treated" human immunodeficiency virus (HIV) infection are cardiovascular disease, malignancy, renal disease, liver disease, bone disease, and perhaps neurological complications, which are phenomena of the normal aging process occurring at an earlier age in the HIV-infected population. The present study is aimed to explore protein carbonyl content as a biomarker for detecting oxidative DNA damage induced ART toxicity and/or accelerated aging in HIV/AIDS patients. To investigate the potential of carbonyl content as a biomarker for detecting oxidative DNA damage induced ART toxicity and/or accelerated aging in HIV/AIDS patients. In this case-control study a total 600 subjects were included. All subjects were randomly selected and grouped as HIV-negative (control group) (n=300), HIV-infected ART naive (n=100), HIV-infected on first line ART (n=100), and HIV-infected on second line ART (n=100). Seronegative control subjects were age- and sex-matched with the ART naive patients and the two other groups. Carbonyl protein was determined by the method described in Levine et al. DNA damage marker 8-OH-dG was determined using 8-hydroxy-2-deoxy Guanosine StressXpress ELA Kit by StressMarq Biosciences. Protein carbonyl content levels and oxidative DNA damage were significantly higher (p<0.05) in HIV-infected patients on second line ART and HIV-infected patients on first line ART than ART naive patients and controls. In a linear regression analysis, increased protein carbonyl content was positively associated with increased DNA damage (OR: 0.356; 95% CI: 0.287-0.426) p<0.05. Carbonyl content may has a role as a biomarker for detecting oxidative DNA damage induced ART toxicity and/or accelerated aging in HIV/AIDS patients. Larger studies are warranted to elucidate the role of carbonyl content as a biomarker for premature aging in HIV/AIDS patients.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 21%
Student > Ph. D. Student 5 15%
Student > Master 4 12%
Student > Postgraduate 3 9%
Student > Bachelor 2 6%
Other 7 21%
Unknown 6 18%
Readers by discipline Count As %
Medicine and Dentistry 13 38%
Nursing and Health Professions 4 12%
Biochemistry, Genetics and Molecular Biology 3 9%
Agricultural and Biological Sciences 1 3%
Psychology 1 3%
Other 2 6%
Unknown 10 29%