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Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis

Overview of attention for article published in BMC Genomics, January 2011
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1 tweeter
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1 Facebook page

Citations

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181 Dimensions

Readers on

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386 Mendeley
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2 CiteULike
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Title
Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis
Published in
BMC Genomics, January 2011
DOI 10.1186/1471-2164-12-14
Pubmed ID
Authors

Brady K Atwood, Jacqueline Lopez, James Wager-Miller, Ken Mackie, Alex Straiker

Abstract

G protein coupled receptors (GPCRs) are one of the most widely studied gene superfamilies. Thousands of GPCR research studies have utilized heterologous expression systems such as human embryonic kidney cells (HEK293). Though often treated as 'blank slates', these cell lines nevertheless endogenously express GPCRs and related signaling proteins. The outcome of a given GPCR study can be profoundly influenced by this largely unknown complement of receptors and/or signaling proteins. Little easily accessible information exists that describes the expression profiles of the GPCRs in cell lines. What is accessible is often limited in scope - of the hundreds of GPCRs and related proteins, one is unlikely to find information on expression of more than a dozen proteins in a given cell line. Microarray technology has allowed rapid analysis of mRNA levels of thousands of candidate genes, but though often publicly available, the results can be difficult to efficiently access or even to interpret.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 386 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 1%
Denmark 3 <1%
Canada 2 <1%
United Kingdom 2 <1%
Portugal 1 <1%
Ukraine 1 <1%
Australia 1 <1%
Belgium 1 <1%
Netherlands 1 <1%
Other 4 1%
Unknown 366 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 110 28%
Researcher 75 19%
Student > Master 46 12%
Student > Bachelor 46 12%
Student > Doctoral Student 21 5%
Other 64 17%
Unknown 24 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 154 40%
Biochemistry, Genetics and Molecular Biology 59 15%
Pharmacology, Toxicology and Pharmaceutical Science 43 11%
Neuroscience 34 9%
Medicine and Dentistry 24 6%
Other 36 9%
Unknown 36 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2015.
All research outputs
#9,508,933
of 12,373,620 outputs
Outputs from BMC Genomics
#5,260
of 7,296 outputs
Outputs of similar age
#94,491
of 143,968 outputs
Outputs of similar age from BMC Genomics
#17
of 26 outputs
Altmetric has tracked 12,373,620 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,296 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 143,968 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.