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Mendeley readers
Attention Score in Context
| Title |
Transcriptional and Functional Profiling of Human Embryonic Stem Cell-Derived Cardiomyocytes
|
|---|---|
| Published in |
PLOS ONE, October 2008
|
| DOI | 10.1371/journal.pone.0003474 |
| Pubmed ID | |
| Authors |
Feng Cao, Roger A. Wagner, Kitchener D. Wilson, Xiaoyan Xie, Ji-Dong Fu, Micha Drukker, Andrew Lee, Ronald A. Li, Sanjiv S. Gambhir, Irving L. Weissman, Robert C. Robbins, Joseph C. Wu |
| Abstract |
Human embryonic stem cells (hESCs) can serve as a potentially limitless source of cells that may enable regeneration of diseased tissue and organs. Here we investigate the use of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) in promoting recovery from cardiac ischemia reperfusion injury in a mouse model. Using microarrays, we have described the hESC-CM transcriptome within the spectrum of changes that occur between undifferentiated hESCs and fetal heart cells. The hESC-CMs expressed cardiomyocyte genes at levels similar to those found in 20-week fetal heart cells, making this population a good source of potential replacement cells in vivo. Echocardiographic studies showed significant improvement in heart function by 8 weeks after transplantation. Finally, we demonstrate long-term engraftment of hESC-CMs by using molecular imaging to track cellular localization, survival, and proliferation in vivo. Taken together, global gene expression profiling of hESC differentiation enables a systems-based analysis of the biological processes, networks, and genes that drive hESC fate decisions, and studies such as this will serve as the foundation for future clinical applications of stem cell therapies. |
Mendeley readers
The data shown below were compiled from readership statistics for 217 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 4% |
| Germany | 2 | <1% |
| Portugal | 1 | <1% |
| Hungary | 1 | <1% |
| United Kingdom | 1 | <1% |
| France | 1 | <1% |
| Belgium | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 201 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 62 | 29% |
| Researcher | 48 | 22% |
| Student > Master | 21 | 10% |
| Professor > Associate Professor | 18 | 8% |
| Student > Bachelor | 13 | 6% |
| Other | 37 | 17% |
| Unknown | 18 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 101 | 47% |
| Biochemistry, Genetics and Molecular Biology | 36 | 17% |
| Medicine and Dentistry | 19 | 9% |
| Engineering | 19 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 2% |
| Other | 16 | 7% |
| Unknown | 21 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2022.
All research outputs
#3,577,470
of 22,705,019 outputs
Outputs from PLOS ONE
#44,304
of 193,828 outputs
Outputs of similar age
#13,453
of 91,057 outputs
Outputs of similar age from PLOS ONE
#107
of 380 outputs
Altmetric has tracked 22,705,019 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 193,828 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 91,057 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 380 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.