Title |
Lethal photosensitization of wound-associated microbes using indocyanine green and near-infrared light
|
---|---|
Published in |
BMC Microbiology, July 2008
|
DOI | 10.1186/1471-2180-8-111 |
Pubmed ID | |
Authors |
Ghada S Omar, Michael Wilson, Sean P Nair |
Abstract |
The increase in resistance to antibiotics among disease-causing bacteria necessitates the development of alternative antimicrobial approaches such as the use of light-activated antimicrobial agents (LAAAs). Light of an appropriate wavelength activates the LAAA to produce cytotoxic species which can then cause bacterial cell death via loss of membrane integrity, lipid peroxidation, the inactivation of essential enzymes, and/or exertion of mutagenic effects due to DNA modification. In this study, the effect of the LAAA indocyanine green excited with high or low intensity light (808 nm) from a near-infrared laser (NIR) on the viability of Staphylococcus aureus, Streptococcus pyogenes and Pseudomonas aeruginosa was investigated. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 2 | 3% |
Turkey | 1 | 2% |
Brazil | 1 | 2% |
United Kingdom | 1 | 2% |
Japan | 1 | 2% |
Unknown | 56 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 24% |
Student > Master | 9 | 15% |
Researcher | 8 | 13% |
Professor > Associate Professor | 4 | 6% |
Student > Bachelor | 4 | 6% |
Other | 11 | 18% |
Unknown | 11 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 23% |
Medicine and Dentistry | 12 | 19% |
Chemistry | 9 | 15% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Engineering | 3 | 5% |
Other | 9 | 15% |
Unknown | 12 | 19% |